Burden of illness for patients with primary biliary cholangitis: an observational study of clinical characteristics and healthcare resource utilization
Aim: To evaluate the clinical characteristics and healthcare resource utilization for acute care and its costs for patients with primary biliary cholangitis (PBC) with or without cirrhosis. Materials & methods: This retrospective observational cohort study was conducted using two datasets (Kom...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Becaris Publishing Limited
2025-03-01
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| Series: | Journal of Comparative Effectiveness Research |
| Subjects: | |
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| Summary: | Aim: To evaluate the clinical characteristics and healthcare resource utilization for acute care and its
costs for patients with primary biliary cholangitis (PBC) with or without cirrhosis. Materials & methods:
This retrospective observational cohort study was conducted using two datasets (Komodo’s Healthcare
Map™ [Komodo Health] and Optum Clinformatics Data Mart [CDM] database) between 2015 and 2023.
Patients (≥18 years) with PBC were identified based on ≥1 inpatient or ≥2 outpatient claims. Healthcare
resource utilization for acute care (hospitalizations and emergency department [ED] visits [not leading to
hospitalization]) were assessed in both datasets, and associated medical costs were evaluated in Optum
CDM. Results: In Komodo Health, of the 29,758 patients with PBC (mean age: 59.2 years), 21.6% had
cirrhosis and 50.4% of patients with cirrhosis had Medicaid or Medicare coverage. Of the total 8143
patients in Optum CDM (mean age: 67.0 years), 20.7% had cirrhosis, and most were enrolled in Medicare
(69.7%). There was a larger proportion of men in the cirrhosis group compared with the no-cirrhosis
group in Komodo Health (31.7 vs 16.3%) and Optum CDM (29.7 vs 16.5%). Annually, among patients
with cirrhosis who had a hospitalization, 69.3% had additional hospitalizations, and among patients
who had an ED visit, 52.9% had additional ED visits in Komodo Health; similar results were observed
in Optum CDM. Among patients with at least one acute-care event, the mean annual acute-care costs
with and without cirrhosis were $113,568 and $47,436, respectively. Conclusion: Data from two large
healthcare claims databases showed that the majority of patients who had at least one acute-care event
experienced additional acute-care events, particularly among those with cirrhosis. Timely treatment to
avoid hospitalization and disease progression may help mitigate the clinical and economic burden for
patients with PBC. |
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| ISSN: | 2042-6313 |