Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections
The paper presents the results of identification of a spectrum of biochemical activity and certification of 140 bacterial strains of I-II risk level deposited in the State collection of pathogenic microorganisms of Scientific centre for expert evaluation of medicinal products of the Ministry of heal...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-02-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
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| Online Access: | https://www.biopreparations.ru/jour/article/view/34 |
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| author | D. S. Davydov M. P. Rudnik A. A. Movsesyants S. M. Chizhonkova V. A. Parashina G. M. Tumanova A. V. Golubeva |
| author_facet | D. S. Davydov M. P. Rudnik A. A. Movsesyants S. M. Chizhonkova V. A. Parashina G. M. Tumanova A. V. Golubeva |
| author_sort | D. S. Davydov |
| collection | DOAJ |
| description | The paper presents the results of identification of a spectrum of biochemical activity and certification of 140 bacterial strains of I-II risk level deposited in the State collection of pathogenic microorganisms of Scientific centre for expert evaluation of medicinal products of the Ministry of health of the Russian Federation. Causative agents of meningitis, dysentery, salmonellosis and other acute gastrointestinal, pyoinflammatory infections, including nosocomial, and other epidemiologically significant infections which can be applied for manufacturing and an quality assessment medicinal and diagnostic preparations, including vaccines, toxoids, therapeutic and prophylactic bacteriophages, antimicrobic drugs, diagnostic serum, test system, nutrient media were evaluated. Correction of a taxonomic nomenclature of collection strains according to requirements of Bergey’s manual of systematic bacteriology (2nd ed) was provided. A possibility of selection of the analogs of cultures of the microorganisms deposited in national collections of other countries and applied by production and quality control of immunobiological medicines and also for quality assessment of laboratory researches is proved. Stability of pivotal phenotypic properties and lack of dissociation master-seed and test strains is confirmed at freeze-drying for over 40 years. |
| format | Article |
| id | doaj-art-e1ec7e02aede4dc1be57e14e1ba78341 |
| institution | Kabale University |
| issn | 2221-996X 2619-1156 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Биопрепараты: Профилактика, диагностика, лечение |
| spelling | doaj-art-e1ec7e02aede4dc1be57e14e1ba783412025-08-20T03:59:39ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0104525834Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infectionsD. S. Davydov0M. P. Rudnik1A. A. Movsesyants2S. M. Chizhonkova3V. A. Parashina4G. M. Tumanova5A. V. Golubeva6Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationFederal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» of the Ministry of Health of the Russian FederationThe paper presents the results of identification of a spectrum of biochemical activity and certification of 140 bacterial strains of I-II risk level deposited in the State collection of pathogenic microorganisms of Scientific centre for expert evaluation of medicinal products of the Ministry of health of the Russian Federation. Causative agents of meningitis, dysentery, salmonellosis and other acute gastrointestinal, pyoinflammatory infections, including nosocomial, and other epidemiologically significant infections which can be applied for manufacturing and an quality assessment medicinal and diagnostic preparations, including vaccines, toxoids, therapeutic and prophylactic bacteriophages, antimicrobic drugs, diagnostic serum, test system, nutrient media were evaluated. Correction of a taxonomic nomenclature of collection strains according to requirements of Bergey’s manual of systematic bacteriology (2nd ed) was provided. A possibility of selection of the analogs of cultures of the microorganisms deposited in national collections of other countries and applied by production and quality control of immunobiological medicines and also for quality assessment of laboratory researches is proved. Stability of pivotal phenotypic properties and lack of dissociation master-seed and test strains is confirmed at freeze-drying for over 40 years.https://www.biopreparations.ru/jour/article/view/34культурально-морфологические свойствареференс- и тест-штаммыбиохимическое типированиедиссоциациякультуральные коллекциинозокомиальные инфекцииcultural and morphological propertiesreference straintest strainbiochemical typingbacterial dissociationculture collectionsnosocomial infections |
| spellingShingle | D. S. Davydov M. P. Rudnik A. A. Movsesyants S. M. Chizhonkova V. A. Parashina G. M. Tumanova A. V. Golubeva Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections Биопрепараты: Профилактика, диагностика, лечение культурально-морфологические свойства референс- и тест-штаммы биохимическое типирование диссоциация культуральные коллекции нозокомиальные инфекции cultural and morphological properties reference strain test strain biochemical typing bacterial dissociation culture collections nosocomial infections |
| title | Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections |
| title_full | Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections |
| title_fullStr | Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections |
| title_full_unstemmed | Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections |
| title_short | Authentification and stability assessment of master-seed and control strains of pathogenic bacteria-causative agents of actual infections |
| title_sort | authentification and stability assessment of master seed and control strains of pathogenic bacteria causative agents of actual infections |
| topic | культурально-морфологические свойства референс- и тест-штаммы биохимическое типирование диссоциация культуральные коллекции нозокомиальные инфекции cultural and morphological properties reference strain test strain biochemical typing bacterial dissociation culture collections nosocomial infections |
| url | https://www.biopreparations.ru/jour/article/view/34 |
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