Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature

We report a 55-year-old female with seropositive rheumatoid arthritis for 10 years who developed large mediastinal and hilar adenopathy while receiving etanercept therapy. Chest high resolution computed tomography (HRCT) showed mediastinal lymph nodes with size of 2.3×3.1 centimeters. Right paratrac...

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Main Authors: Supat Thongpooswan, Adriana Abrudescu
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2014/358567
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author Supat Thongpooswan
Adriana Abrudescu
author_facet Supat Thongpooswan
Adriana Abrudescu
author_sort Supat Thongpooswan
collection DOAJ
description We report a 55-year-old female with seropositive rheumatoid arthritis for 10 years who developed large mediastinal and hilar adenopathy while receiving etanercept therapy. Chest high resolution computed tomography (HRCT) showed mediastinal lymph nodes with size of 2.3×3.1 centimeters. Right paratracheal lymph node biopsy showed nonnecrotizing epithelioid granulomata. All infectious studies of pulmonary lymph node tissues were negative. Etanercept was discontinued. Follow-up HRCT 6 months later showed resolution of mediastinal lymph nodes. This report should increase awareness of pulmonary sarcoidosis development in patient treated with tumor necrosis factor-alpha blocking agent, etanercept.
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spelling doaj-art-e1ea4a65a3274100875c533c3420deeb2025-02-03T01:10:31ZengWileyCase Reports in Rheumatology2090-68892090-68972014-01-01201410.1155/2014/358567358567Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the LiteratureSupat Thongpooswan0Adriana Abrudescu1Mount Sinai School of Medicine, Queens Hospital Center, Jamaica, NY 11432, USAMount Sinai School of Medicine, Queens Hospital Center, Jamaica, NY 11432, USAWe report a 55-year-old female with seropositive rheumatoid arthritis for 10 years who developed large mediastinal and hilar adenopathy while receiving etanercept therapy. Chest high resolution computed tomography (HRCT) showed mediastinal lymph nodes with size of 2.3×3.1 centimeters. Right paratracheal lymph node biopsy showed nonnecrotizing epithelioid granulomata. All infectious studies of pulmonary lymph node tissues were negative. Etanercept was discontinued. Follow-up HRCT 6 months later showed resolution of mediastinal lymph nodes. This report should increase awareness of pulmonary sarcoidosis development in patient treated with tumor necrosis factor-alpha blocking agent, etanercept.http://dx.doi.org/10.1155/2014/358567
spellingShingle Supat Thongpooswan
Adriana Abrudescu
Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
Case Reports in Rheumatology
title Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
title_full Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
title_fullStr Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
title_full_unstemmed Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
title_short Lung Sarcoidosis in Etanercept Treated Rheumatoid Arthritis Patient: A Case Report and Review of the Literature
title_sort lung sarcoidosis in etanercept treated rheumatoid arthritis patient a case report and review of the literature
url http://dx.doi.org/10.1155/2014/358567
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