Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study
Abstract Background Urinary tract infections (UTIs) are a common health problem worldwide, leading to increased morbidity, mortality, and healthcare costs. Data on the prevalence of urinary tract infections, antimicrobial susceptibility patterns, and the associated factors are scarce in the study ar...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-10788-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850184784528015360 |
|---|---|
| author | Abdi Diriba Seifu Gizaw Fedasan Alemu Kume Tesfaye Endalu Tesfaye Motuma Chali Girmaye Jobir |
| author_facet | Abdi Diriba Seifu Gizaw Fedasan Alemu Kume Tesfaye Endalu Tesfaye Motuma Chali Girmaye Jobir |
| author_sort | Abdi Diriba |
| collection | DOAJ |
| description | Abstract Background Urinary tract infections (UTIs) are a common health problem worldwide, leading to increased morbidity, mortality, and healthcare costs. Data on the prevalence of urinary tract infections, antimicrobial susceptibility patterns, and the associated factors are scarce in the study area. Therefore, the aim of this study was to determine the prevalence, antimicrobial susceptibility patterns and associated factors among urinary tract infections suspected patients. Methods A hospital-based cross-sectional study was conducted at Nekemte Comprehensive Specialized Hospital, from June to September 2024 among 270 participants. Midstream urine samples were collected under aseptic techniques. Then samples were cultured on blood and MacConkey agars following standard microbiological techniques. Antimicrobial sensitivity testing was performed using the disc diffusion (Kirby-Bauer) method. The data were checked for completeness and consistency, entered into Epi Data version 4.6, and analyzed by Statistical Package for Social Sciences (SPSS) version 26. Logistic regression analysis was performed to determine the associated factors of urinary tract infections. P-value < 0.05 was considered statistically significant. Result Of the total samples collected, 78/270 (28.9%) had significant bacteriuria. Gram-negative and gram-positive bacteria accounted for 67/78 (85.9%) and 11/78 (14.1%), among which Escherichia coli was the most prevalent, 30/78 (38.5%), followed by Klebsiella species, 26/78 (33.3%). Gram-positive isolates were highly susceptible to gentamicin (100%) and clindamycin (88.9%). Gram-negative bacteria showed high-level susceptibility to amikacin (100%), cefepime (93.3%), and gentamicin (91.0%). The total multidrug resistance identified was 44/78 (56.4%). Female gender, a having history of UTI, and antibiotic use without a prescription were statistically significant with UTI. Conclusion and recommendation Most of the isolated uropathogens were multidrug-resistant. A significant association with UTI was observed with being female, having a previous history of UTI, and using antibiotic without a prescription. Treatment of UTI should be supported by culture and antimicrobial susceptibility patterns. |
| format | Article |
| id | doaj-art-e1e86e2fa03e44a08f9213c17aba80d7 |
| institution | OA Journals |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-e1e86e2fa03e44a08f9213c17aba80d72025-08-20T02:16:56ZengBMCBMC Infectious Diseases1471-23342025-04-0125111210.1186/s12879-025-10788-8Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional studyAbdi Diriba0Seifu Gizaw1Fedasan Alemu2Kume Tesfaye3Endalu Tesfaye4Motuma Chali5Girmaye Jobir6Department of Medical Laboratory Sciences, College of Health Sciences, Salale UniversityDepartment of Medical Laboratory Sciences, College of Health Sciences, Salale UniversityDepartment of Medical Laboratory Sciences, College of Health Sciences, Salale UniversityDepartment of Medical Laboratory Sciences, College of Health Sciences, Salale UniversityClinical Microbiology Diagnostic and Research Laboratory, Nekemte Public Health Research and Referral Laboratory CenterClinical Microbiology Diagnostic and Research Laboratory, Nekemte Public Health Research and Referral Laboratory CenterDepartment of Medical Laboratory Sciences, Institute of Health Sciences, Wallaga UniversityAbstract Background Urinary tract infections (UTIs) are a common health problem worldwide, leading to increased morbidity, mortality, and healthcare costs. Data on the prevalence of urinary tract infections, antimicrobial susceptibility patterns, and the associated factors are scarce in the study area. Therefore, the aim of this study was to determine the prevalence, antimicrobial susceptibility patterns and associated factors among urinary tract infections suspected patients. Methods A hospital-based cross-sectional study was conducted at Nekemte Comprehensive Specialized Hospital, from June to September 2024 among 270 participants. Midstream urine samples were collected under aseptic techniques. Then samples were cultured on blood and MacConkey agars following standard microbiological techniques. Antimicrobial sensitivity testing was performed using the disc diffusion (Kirby-Bauer) method. The data were checked for completeness and consistency, entered into Epi Data version 4.6, and analyzed by Statistical Package for Social Sciences (SPSS) version 26. Logistic regression analysis was performed to determine the associated factors of urinary tract infections. P-value < 0.05 was considered statistically significant. Result Of the total samples collected, 78/270 (28.9%) had significant bacteriuria. Gram-negative and gram-positive bacteria accounted for 67/78 (85.9%) and 11/78 (14.1%), among which Escherichia coli was the most prevalent, 30/78 (38.5%), followed by Klebsiella species, 26/78 (33.3%). Gram-positive isolates were highly susceptible to gentamicin (100%) and clindamycin (88.9%). Gram-negative bacteria showed high-level susceptibility to amikacin (100%), cefepime (93.3%), and gentamicin (91.0%). The total multidrug resistance identified was 44/78 (56.4%). Female gender, a having history of UTI, and antibiotic use without a prescription were statistically significant with UTI. Conclusion and recommendation Most of the isolated uropathogens were multidrug-resistant. A significant association with UTI was observed with being female, having a previous history of UTI, and using antibiotic without a prescription. Treatment of UTI should be supported by culture and antimicrobial susceptibility patterns.https://doi.org/10.1186/s12879-025-10788-8BacteriaUrinary tract infectionMultidrug resistance |
| spellingShingle | Abdi Diriba Seifu Gizaw Fedasan Alemu Kume Tesfaye Endalu Tesfaye Motuma Chali Girmaye Jobir Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study BMC Infectious Diseases Bacteria Urinary tract infection Multidrug resistance |
| title | Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study |
| title_full | Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study |
| title_fullStr | Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study |
| title_full_unstemmed | Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study |
| title_short | Prevalence, antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending Nekemte Comprehensive Specialized Hospital, Western Ethiopia, 2024: a cross-sectional study |
| title_sort | prevalence antimicrobial sensitivity patterns and associated factors of urinary tract infection among patients attending nekemte comprehensive specialized hospital western ethiopia 2024 a cross sectional study |
| topic | Bacteria Urinary tract infection Multidrug resistance |
| url | https://doi.org/10.1186/s12879-025-10788-8 |
| work_keys_str_mv | AT abdidiriba prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT seifugizaw prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT fedasanalemu prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT kumetesfaye prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT endalutesfaye prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT motumachali prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy AT girmayejobir prevalenceantimicrobialsensitivitypatternsandassociatedfactorsofurinarytractinfectionamongpatientsattendingnekemtecomprehensivespecializedhospitalwesternethiopia2024acrosssectionalstudy |