Protein phosphatase-1 regulates the binding of filamin C to FILIP1 in cultured skeletal muscle cells under mechanical stress

Abstract The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc acts as a signaling adaptor which is phosphorylated at S2234 in its mechanosensitive domain 20 (d20) through...

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Bibliographic Details
Main Authors: Thomas Kokot, Johannes P. Zimmermann, Anja N. Schwäble, Lena Reimann, Anna L. Herr, Nico Höfflin, Maja Köhn, Bettina Warscheid
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-78953-8
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