An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study
In this report, we have presented our experience about a facile method for synthesis of tofacitinib citrate (TFC). The developed analytical methods for identification and qualifications are also included. As TFC seems to be effective in treatment of the symptoms of COVID-19 (SARS family), manufactur...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/8759235 |
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| author | Seyyed Amir Siadati Mehdi Soheilizad Loghman Firoozpour Marjan Samadi Meghdad Payab Saeed Bagherpour Seyyed Mehdi Mousavi |
| author_facet | Seyyed Amir Siadati Mehdi Soheilizad Loghman Firoozpour Marjan Samadi Meghdad Payab Saeed Bagherpour Seyyed Mehdi Mousavi |
| author_sort | Seyyed Amir Siadati |
| collection | DOAJ |
| description | In this report, we have presented our experience about a facile method for synthesis of tofacitinib citrate (TFC). The developed analytical methods for identification and qualifications are also included. As TFC seems to be effective in treatment of the symptoms of COVID-19 (SARS family), manufacturing of this active pharmaceutical ingredient (API) could be helpful. The API of TFC was prepared from the diamine intermediate in an ambient and solvent-free condition. Elimination of the reaction solvent resulted in decreasing the cost and preventing the rejection of the organic volatile impurity (OVI) test. The final citrate addition step was carried out using water as a solvent (the citrate content was 37.5% by potentiometry). Moreover, the results of the Karl-Fischer (KF) titration analysis was about 0.24%, which showed that the use of water does not increase the water content of the crystal structure. |
| format | Article |
| id | doaj-art-e1df87414d9b433886239b23eaffdf02 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-e1df87414d9b433886239b23eaffdf022025-02-03T00:59:37ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/8759235An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical StudySeyyed Amir Siadati0Mehdi Soheilizad1Loghman Firoozpour2Marjan Samadi3Meghdad Payab4Saeed Bagherpour5Seyyed Mehdi Mousavi6Department of Research & DevelopmentDepartment of Research & DevelopmentDepartment of Research & DevelopmentDepartment of Research & DevelopmentFaculty of ChemistryDepartment of Research & DevelopmentDepartment of Research & DevelopmentIn this report, we have presented our experience about a facile method for synthesis of tofacitinib citrate (TFC). The developed analytical methods for identification and qualifications are also included. As TFC seems to be effective in treatment of the symptoms of COVID-19 (SARS family), manufacturing of this active pharmaceutical ingredient (API) could be helpful. The API of TFC was prepared from the diamine intermediate in an ambient and solvent-free condition. Elimination of the reaction solvent resulted in decreasing the cost and preventing the rejection of the organic volatile impurity (OVI) test. The final citrate addition step was carried out using water as a solvent (the citrate content was 37.5% by potentiometry). Moreover, the results of the Karl-Fischer (KF) titration analysis was about 0.24%, which showed that the use of water does not increase the water content of the crystal structure.http://dx.doi.org/10.1155/2022/8759235 |
| spellingShingle | Seyyed Amir Siadati Mehdi Soheilizad Loghman Firoozpour Marjan Samadi Meghdad Payab Saeed Bagherpour Seyyed Mehdi Mousavi An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study Journal of Chemistry |
| title | An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study |
| title_full | An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study |
| title_fullStr | An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study |
| title_full_unstemmed | An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study |
| title_short | An Industrial Approach to Production of Tofacitinib Citrate (TFC) as an Anti-COVID-19 Agent: A Joint Experimental and Theoretical Study |
| title_sort | industrial approach to production of tofacitinib citrate tfc as an anti covid 19 agent a joint experimental and theoretical study |
| url | http://dx.doi.org/10.1155/2022/8759235 |
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