Plastic additive bisphenol S induces depression by promoting AZU1/CTSD proteins to mediate plasma-related proteins and metabolites: A comprehensive multi-omics analysis

Plastic additive bisphenol S induces depression by promoting AZU1/CTSD proteins to mediate plasma-related proteins and metabolites: A comprehensive multi-omics analysis

Background: The role of bisphenol S (BPS) in the pathogenesis of depression still unclear, particularly regarding its underlying mechanisms and causality. Methods: In this study, network toxicology approaches were employed to explore the mechanisms underlying BPS-induced depression, and Mendelian ra...

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Bibliographic Details
Main Authors: Ni-ren Li, Pai Xie, Yi-xuan Zeng, Bing-ying Deng, Si-fan Lu, Yu-feng Gu, Yanhong Ma, Chao-hua Luo, Yi Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Network toxicology
Mendelian randomization
Molecular dynamics
AZU1/CTSD protein
Bisphenol S
Depression
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325010620
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