Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study
Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/3845067 |
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| author | Duc Trong Quach Mai Ngoc Luu Toru Hiyama Thuy-HuongThi To Quy Nhuan Bui Tuan Anh Tran Binh Duy Tran Minh-Cong Hong Vo Shinji Tanaka Naomi Uemura |
| author_facet | Duc Trong Quach Mai Ngoc Luu Toru Hiyama Thuy-HuongThi To Quy Nhuan Bui Tuan Anh Tran Binh Duy Tran Minh-Cong Hong Vo Shinji Tanaka Naomi Uemura |
| author_sort | Duc Trong Quach |
| collection | DOAJ |
| description | Aims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive. Patients were divided into group A (RUT plus noninvasive tests) and group B (only noninvasive tests). Results. The overall H. pylori infection rate was 94.2% (161/171). Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use. H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%, p=0.004). The positive rate of RUT was similar at each biopsy site but significantly increased if RUT results from 2 or 3 sites were combined (p<0.05). Conclusions. H. pylori infection rate in Vietnamese patients with acute PUB is high. RUT is an excellent test if at least 2 biopsies are taken. |
| format | Article |
| id | doaj-art-e1c5b6817cef46f1b00c133231533424 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e1c5b6817cef46f1b00c1332315334242025-02-03T06:00:38ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/38450673845067Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective StudyDuc Trong Quach0Mai Ngoc Luu1Toru Hiyama2Thuy-HuongThi To3Quy Nhuan Bui4Tuan Anh Tran5Binh Duy Tran6Minh-Cong Hong Vo7Shinji Tanaka8Naomi Uemura9Department of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh, VietnamDepartment of Internal Medicine, University of Medicine and Pharmacy, Ho Chi Minh, VietnamHealth Service Center, Hiroshima University, Higashihiroshima, JapanDepartment of Endoscopy, Gia Dinh People’s Hospital, Ho Chi Minh City, VietnamDepartment of Endoscopy, Gia Dinh People’s Hospital, Ho Chi Minh City, VietnamDepartment of Endoscopy, Gia Dinh People’s Hospital, Ho Chi Minh City, VietnamDepartment of Endoscopy, Gia Dinh People’s Hospital, Ho Chi Minh City, VietnamDepartment of Gastroenterology, Gia Dinh People’s Hospital, Ho Chi Minh City, VietnamDepartment of Endoscopy, Hiroshima University Hospital, Hiroshima, JapanDepartment of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Ichikawa, JapanAims. To investigate H. pylori infection rate and evaluate a combined set of tests for H. pylori diagnosis in Vietnamese patients with acute peptic ulcer bleeding (PUD). Methods. Consecutive patients with acute PUB were enrolled prospectively. Rapid urease test (RUT) with 3 biopsies was carried out randomly. Patients without RUT or with negative RUT received urea breath test (UBT) and serological and urinary H. pylori antibody tests. H. pylori was considered positive if RUT or any noninvasive test was positive. Patients were divided into group A (RUT plus noninvasive tests) and group B (only noninvasive tests). Results. The overall H. pylori infection rate was 94.2% (161/171). Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use. H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%, p=0.004). The positive rate of RUT was similar at each biopsy site but significantly increased if RUT results from 2 or 3 sites were combined (p<0.05). Conclusions. H. pylori infection rate in Vietnamese patients with acute PUB is high. RUT is an excellent test if at least 2 biopsies are taken.http://dx.doi.org/10.1155/2017/3845067 |
| spellingShingle | Duc Trong Quach Mai Ngoc Luu Toru Hiyama Thuy-HuongThi To Quy Nhuan Bui Tuan Anh Tran Binh Duy Tran Minh-Cong Hong Vo Shinji Tanaka Naomi Uemura Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study Gastroenterology Research and Practice |
| title | Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study |
| title_full | Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study |
| title_fullStr | Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study |
| title_full_unstemmed | Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study |
| title_short | Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study |
| title_sort | early diagnosis of helicobacter pylori infection in vietnamese patients with acute peptic ulcer bleeding a prospective study |
| url | http://dx.doi.org/10.1155/2017/3845067 |
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