Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in he...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e054336.full |
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| author | Nick Andrews Mary Ramsay Maria Zambon Victoria Hall Sarah Wallace Susan Hopkins Jean Timeyin Tim J G Brooks Amoolya Vusirikala Meera Chand Andre Charlett Sakib Rokadiya Colin S Brown Madhumita Shrotri Peter D Kirwan Michele Cole Natalie Gillson Ana Atti Sarah Foulkes Andrew Taylor-Kerr Blanche Oguti Jasmin Islam |
| author_facet | Nick Andrews Mary Ramsay Maria Zambon Victoria Hall Sarah Wallace Susan Hopkins Jean Timeyin Tim J G Brooks Amoolya Vusirikala Meera Chand Andre Charlett Sakib Rokadiya Colin S Brown Madhumita Shrotri Peter D Kirwan Michele Cole Natalie Gillson Ana Atti Sarah Foulkes Andrew Taylor-Kerr Blanche Oguti Jasmin Islam |
| author_sort | Nick Andrews |
| collection | DOAJ |
| description | Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection.Methods and analysis This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres.Ethics and dissemination The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making.Trial registration number ISRCTN11041050. |
| format | Article |
| id | doaj-art-e1c3073da52a4eb5b7d7f5579b8bf5fb |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e1c3073da52a4eb5b7d7f5579b8bf5fb2025-01-27T18:50:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-054336Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocolNick Andrews0Mary Ramsay1Maria Zambon2Victoria Hall3Sarah Wallace4Susan Hopkins5Jean Timeyin6Tim J G Brooks7Amoolya Vusirikala8Meera Chand9Andre Charlett10Sakib Rokadiya11Colin S Brown12Madhumita Shrotri13Peter D Kirwan14Michele Cole15Natalie Gillson16Ana Atti17Sarah Foulkes18Andrew Taylor-Kerr19Blanche Oguti20Jasmin Islam21London School of Hygiene and Tropical Medicine, National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London, UKImmunisation and Vaccine Preventable Diseases, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKUK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKUK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKIntroduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection.Methods and analysis This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres.Ethics and dissemination The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making.Trial registration number ISRCTN11041050.https://bmjopen.bmj.com/content/12/6/e054336.full |
| spellingShingle | Nick Andrews Mary Ramsay Maria Zambon Victoria Hall Sarah Wallace Susan Hopkins Jean Timeyin Tim J G Brooks Amoolya Vusirikala Meera Chand Andre Charlett Sakib Rokadiya Colin S Brown Madhumita Shrotri Peter D Kirwan Michele Cole Natalie Gillson Ana Atti Sarah Foulkes Andrew Taylor-Kerr Blanche Oguti Jasmin Islam Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol BMJ Open |
| title | Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol |
| title_full | Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol |
| title_fullStr | Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol |
| title_full_unstemmed | Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol |
| title_short | Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol |
| title_sort | impact of prior sars cov 2 infection and covid 19 vaccination on the subsequent incidence of covid 19 a multicentre prospective cohort study among uk healthcare workers the siren sarscov2 immunity reinfection evaluation study protocol |
| url | https://bmjopen.bmj.com/content/12/6/e054336.full |
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