Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol

Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in he...

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Main Authors: Nick Andrews, Mary Ramsay, Maria Zambon, Victoria Hall, Sarah Wallace, Susan Hopkins, Jean Timeyin, Tim J G Brooks, Amoolya Vusirikala, Meera Chand, Andre Charlett, Sakib Rokadiya, Colin S Brown, Madhumita Shrotri, Peter D Kirwan, Michele Cole, Natalie Gillson, Ana Atti, Sarah Foulkes, Andrew Taylor-Kerr, Blanche Oguti, Jasmin Islam
Format: Article
Language:English
Published: BMJ Publishing Group 2022-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/12/6/e054336.full
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author Nick Andrews
Mary Ramsay
Maria Zambon
Victoria Hall
Sarah Wallace
Susan Hopkins
Jean Timeyin
Tim J G Brooks
Amoolya Vusirikala
Meera Chand
Andre Charlett
Sakib Rokadiya
Colin S Brown
Madhumita Shrotri
Peter D Kirwan
Michele Cole
Natalie Gillson
Ana Atti
Sarah Foulkes
Andrew Taylor-Kerr
Blanche Oguti
Jasmin Islam
author_facet Nick Andrews
Mary Ramsay
Maria Zambon
Victoria Hall
Sarah Wallace
Susan Hopkins
Jean Timeyin
Tim J G Brooks
Amoolya Vusirikala
Meera Chand
Andre Charlett
Sakib Rokadiya
Colin S Brown
Madhumita Shrotri
Peter D Kirwan
Michele Cole
Natalie Gillson
Ana Atti
Sarah Foulkes
Andrew Taylor-Kerr
Blanche Oguti
Jasmin Islam
author_sort Nick Andrews
collection DOAJ
description Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection.Methods and analysis This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres.Ethics and dissemination The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making.Trial registration number ISRCTN11041050.
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spelling doaj-art-e1c3073da52a4eb5b7d7f5579b8bf5fb2025-01-27T18:50:10ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-054336Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocolNick Andrews0Mary Ramsay1Maria Zambon2Victoria Hall3Sarah Wallace4Susan Hopkins5Jean Timeyin6Tim J G Brooks7Amoolya Vusirikala8Meera Chand9Andre Charlett10Sakib Rokadiya11Colin S Brown12Madhumita Shrotri13Peter D Kirwan14Michele Cole15Natalie Gillson16Ana Atti17Sarah Foulkes18Andrew Taylor-Kerr19Blanche Oguti20Jasmin Islam21London School of Hygiene and Tropical Medicine, National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Vaccines and Immunisation, London, UKImmunisation and Vaccine Preventable Diseases, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKUK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKUK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKNational Infection Service, UK Health Security Agency, London, UKIntroduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection.Methods and analysis This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months.The primary outcome of interest is infection with SARS-CoV-2 after previous SARS-CoV-2 infection or COVID-19 vaccination during the study period. Secondary outcomes include incidence and prevalence (both RNA and antibody) of SARS-CoV-2, viral genomics, viral culture, symptom history and antibody/neutralising antibody titres.Ethics and dissemination The study was approved by the Berkshire Research Ethics Committee, Health Research Authority (IRAS ID 284460, REC reference 20/SC/0230) on 22 May 2020; the vaccine amendment was approved on 12 January 2021. Participants gave informed consent before taking part in the study.Regular reports to national and international expert advisory groups and peer-reviewed publications ensure timely dissemination of findings to inform decision making.Trial registration number ISRCTN11041050.https://bmjopen.bmj.com/content/12/6/e054336.full
spellingShingle Nick Andrews
Mary Ramsay
Maria Zambon
Victoria Hall
Sarah Wallace
Susan Hopkins
Jean Timeyin
Tim J G Brooks
Amoolya Vusirikala
Meera Chand
Andre Charlett
Sakib Rokadiya
Colin S Brown
Madhumita Shrotri
Peter D Kirwan
Michele Cole
Natalie Gillson
Ana Atti
Sarah Foulkes
Andrew Taylor-Kerr
Blanche Oguti
Jasmin Islam
Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
BMJ Open
title Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
title_full Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
title_fullStr Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
title_full_unstemmed Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
title_short Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol
title_sort impact of prior sars cov 2 infection and covid 19 vaccination on the subsequent incidence of covid 19 a multicentre prospective cohort study among uk healthcare workers the siren sarscov2 immunity reinfection evaluation study protocol
url https://bmjopen.bmj.com/content/12/6/e054336.full
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