Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions
Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract containing baicalin and catechin...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/790851 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556024925519872 |
|---|---|
| author | Alessandra Bitto Francesco Squadrito Natasha Irrera Gabriele Pizzino Giovanni Pallio Anna Mecchio Federica Galfo Domenica Altavilla |
| author_facet | Alessandra Bitto Francesco Squadrito Natasha Irrera Gabriele Pizzino Giovanni Pallio Anna Mecchio Federica Galfo Domenica Altavilla |
| author_sort | Alessandra Bitto |
| collection | DOAJ |
| description | Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro. Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen. Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions. |
| format | Article |
| id | doaj-art-e1bd5e9fed504b429c90cc5b8039fcf9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e1bd5e9fed504b429c90cc5b8039fcf92025-02-03T05:46:34ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/790851790851Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory ConditionsAlessandra Bitto0Francesco Squadrito1Natasha Irrera2Gabriele Pizzino3Giovanni Pallio4Anna Mecchio5Federica Galfo6Domenica Altavilla7Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Torre Biologica 5th Floor, AOU Policlinico “G. Martino’’, Via C. Valeria Gazzi, 98125 Messina, ItalyDepartment of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria Gazzi, 98125 Messina, ItalyFlavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro. Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen. Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.http://dx.doi.org/10.1155/2014/790851 |
| spellingShingle | Alessandra Bitto Francesco Squadrito Natasha Irrera Gabriele Pizzino Giovanni Pallio Anna Mecchio Federica Galfo Domenica Altavilla Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions Mediators of Inflammation |
| title | Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions |
| title_full | Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions |
| title_fullStr | Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions |
| title_full_unstemmed | Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions |
| title_short | Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions |
| title_sort | flavocoxid a nutraceutical approach to blunt inflammatory conditions |
| url | http://dx.doi.org/10.1155/2014/790851 |
| work_keys_str_mv | AT alessandrabitto flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT francescosquadrito flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT natashairrera flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT gabrielepizzino flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT giovannipallio flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT annamecchio flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT federicagalfo flavocoxidanutraceuticalapproachtobluntinflammatoryconditions AT domenicaaltavilla flavocoxidanutraceuticalapproachtobluntinflammatoryconditions |