Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents
New series of 4-(substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3-thiol (4a-c), N³-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3,4-diamine (5a-c) and N-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-1,3,4-thiadiazol-2-amine (6a-g) have be...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/249245 |
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| author | Jyoti Sharma Sabir Hussain Mohammad Amir |
| author_facet | Jyoti Sharma Sabir Hussain Mohammad Amir |
| author_sort | Jyoti Sharma |
| collection | DOAJ |
| description | New series of 4-(substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3-thiol (4a-c), N³-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3,4-diamine (5a-c) and N-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-1,3,4-thiadiazol-2-amine (6a-g) have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antimicrobial activity (MIC activity) was evaluated and compared with standard drugs of loxacin and ketoconazole. Compounds 5a and 6e in the series have shown interesting antibacterial activity against both S. aureus (gram-positive) and E. coli (gram-negative) organisms. In this paper, we also describe studies leading to identification of antifungal agents. In the gratifying result, most of the compounds were found to have moderate antimicrobial activity. |
| format | Article |
| id | doaj-art-e1babd36ee1b4765987d54ff01d26152 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e1babd36ee1b4765987d54ff01d261522025-02-03T01:33:04ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015S1S1008S101410.1155/2008/249245Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial AgentsJyoti Sharma0Sabir Hussain1Mohammad Amir2Department of Chemistry, R. R. College, Alwar, Rajasthan, IndiaDepartment of Chemistry, R. R. College, Alwar, Rajasthan, IndiaDepartment of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, IndiaNew series of 4-(substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3-thiol (4a-c), N³-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3,4-diamine (5a-c) and N-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-1,3,4-thiadiazol-2-amine (6a-g) have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antimicrobial activity (MIC activity) was evaluated and compared with standard drugs of loxacin and ketoconazole. Compounds 5a and 6e in the series have shown interesting antibacterial activity against both S. aureus (gram-positive) and E. coli (gram-negative) organisms. In this paper, we also describe studies leading to identification of antifungal agents. In the gratifying result, most of the compounds were found to have moderate antimicrobial activity.http://dx.doi.org/10.1155/2008/249245 |
| spellingShingle | Jyoti Sharma Sabir Hussain Mohammad Amir Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents E-Journal of Chemistry |
| title | Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents |
| title_full | Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents |
| title_fullStr | Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents |
| title_full_unstemmed | Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents |
| title_short | Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents |
| title_sort | synthesis and study of some newer analogues ofquinolin 8 ol as potent antimicrobial agents |
| url | http://dx.doi.org/10.1155/2008/249245 |
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