Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury

Prostaglandin E2 receptor EP4 activation induces tolerogenic dendritic cells to mitigate ischemic acute kidney injury

Abstract The prevalence and mortality rates of acute kidney injury (AKI) remain high, with ischemia-reperfusion (I/R) being a major cause in clinical settings. Dendritic cells (DCs) play a crucial role in inducing the infiltration of inflammatory cells into the kidneys during I/R, leading to persist...

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Bibliographic Details
Main Authors: Chunyao Li, Caiping Yang, Pingping Wang, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Ying Zhang, Qin Ma, Tao Peng, Jie Xu, Ting Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Prostaglandin E2
EP4
Dendritic cells
Ischemia-reperfusion
Acute kidney injury
Online Access:https://doi.org/10.1038/s41598-025-03085-6
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