A biochemical screening platform to target chromatin states using condensates as a tool

A biochemical screening platform to target chromatin states using condensates as a tool

Chromatin states define cell fates and consequently dysfunctional chromatin states drive disease. Conventional approaches to target dysfunctional chromatin states typically rely on targeting a defined, structured binding pocket of a specific chromatin protein. However, drugs developed from targeting...

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Bibliographic Details
Main Authors: Laura J. Hsieh, Tracy Lou, Muryam A. Gourdet, Emily Wong, Geeta J. Narlikar
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:SLAS Discovery
Subjects:
Chromatin
Condensates
PPIs
IDRs
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000292
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