Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks
<p>The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of <mml:math alttext="$2...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/62868 |
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| Summary: | <p>The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of <mml:math alttext="$24.42pm 1.22$"> <mml:mrow><mml:mn>24.42</mml:mn><mml:mo>±</mml:mo><mml:mn>1.22</mml:mn> </mml:mrow></mml:math> (Mean <mml:math alttext="$pm$"><mml:mo>±</mml:mo></mml:math> SEM) years and <mml:math alttext="$24.30pm1.19$"><mml:mrow><mml:mn>24.30</mml:mn><mml:mo>±</mml:mo><mml:mn>1.19</mml:mn></mml:mrow></mml:math> years (Mean <mml:math alttext="$pm$"><mml:mo>±</mml:mo></mml:math> SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR),} C-reactive protein (CRP),fibrinogen, and leukocyte counts before the attack and 8–12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were <mml:math alttext="$6.45pm 1.05$"><mml:mrow><mml:mn>6.45</mml:mn><mml:mo>±</mml:mo><mml:mn>2.81</mml:mn></mml:mrow></mml:math> (Mean <mml:math alttext="$pm$"><mml:mo>±</mml:mo></mml:math> SEM) and during the attacks were <mml:math alttext="$7.59pm 1.3$"><mml:mrow><mml:mn>7.59</mml:mn><mml:mo>±</mml:mo><mml:mn>1.3</mml:mn></mml:mrow></mml:math> (Mean <mml:math alttext="$pm$"><mml:mo>±</mml:mo></mml:math> SEM) in FMF group,respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (<mml:math alttext="$P>.05$"><mml:mrow><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). The mean serum leptin levels were <mml:math alttext="$6.12 pm 2.81$"><mml:mrow><mml:mn>16.12</mml:mn><mml:mo>±</mml:mo><mml:mn>1.05</mml:mn></mml:mrow></mml:math> in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (<mml:math alttext="$P>.05$"><mml:mrow><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (<mml:math alttext="$P>.05$"><mml:mrow><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (<mml:math alttext="$P>.05$"><mml:mrow><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn>.05</mml:mn></mml:mrow></mml:math>). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.</p> |
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| ISSN: | 0962-9351 |