METTL1-driven nucleotide metabolism reprograms the immune microenvironment in hepatocellular carcinoma: a multi-omics approach for prognostic biomarker discovery

METTL1-driven nucleotide metabolism reprograms the immune microenvironment in hepatocellular carcinoma: a multi-omics approach for prognostic biomarker discovery

BackgroundHepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, partly due to an incomplete understanding of the metabolic and immune dysregulation driving its progression. Here, we uncover a novel role of METTL1 in driving nucleotide metabolism repr...

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Bibliographic Details
Main Authors: Xie Weng, Yangyue Huang, Zhuoya Fu, Xingli Liu, Fuli Xie, Jiale Wang, Qiaohua Zhu, Dayong Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
pancreatic hepatocellular carcinoma
nucleotide metabolism
non-negative matrix factorization clustering
immune cell correlation
METTL1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1582203/full
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