Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD
The objective of the present study was to determine the association between CT phenotypes—emphysema by low attenuation area and bronchitis by airway wall thickness—and body composition parameters in a large cohort of subjects with and without COPD. In 452 COPD subjects and 459 subjects without COPD,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/419328 |
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| author | Erica P. A. Rutten Thomas B. Grydeland Sreekumar G. Pillai Scott Wagers Asger Dirksen Harvey O. Coxson Amund Gulsvik Emiel F. M. Wouters Per S. Bakke |
| author_facet | Erica P. A. Rutten Thomas B. Grydeland Sreekumar G. Pillai Scott Wagers Asger Dirksen Harvey O. Coxson Amund Gulsvik Emiel F. M. Wouters Per S. Bakke |
| author_sort | Erica P. A. Rutten |
| collection | DOAJ |
| description | The objective of the present study was to determine the association between CT phenotypes—emphysema by low attenuation area and bronchitis by airway wall thickness—and body composition parameters in a large cohort of subjects with and without COPD. In 452 COPD subjects and 459 subjects without COPD, CT scans were performed to determine emphysema (%LAA), airway wall thickness (AWT-Pi10), and lung mass. Muscle wasting based on FFMI was assessed by bioelectrical impedance. In both the men and women with COPD, FFMI was negatively associated with %LAA. FMI was positively associated with AWT-Pi10 in both subjects with and without COPD. Among the subjects with muscle wasting, the percentage emphysema was high, but the predictive value was moderate. In conclusion, the present study strengthens the hypothesis that the subgroup of COPD cases with muscle wasting have emphysema. Airway wall thickness is positively associated with fat mass index in both subjects with and without COPD. |
| format | Article |
| id | doaj-art-e1a9347183c24171a7e5c71e55f84ea3 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-e1a9347183c24171a7e5c71e55f84ea32025-02-03T01:02:29ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/419328419328Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPDErica P. A. Rutten0Thomas B. Grydeland1Sreekumar G. Pillai2Scott Wagers3Asger Dirksen4Harvey O. Coxson5Amund Gulsvik6Emiel F. M. Wouters7Per S. Bakke8Center of Expertise for Chronic Organ Failure (Ciro), 6085 NM Horn, The NetherlandsDepartment of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, NorwayGlaxoSmithKline, Research Triangle Park, 27709 NC, USACenter of Expertise for Chronic Organ Failure (Ciro), 6085 NM Horn, The NetherlandsDepartment of Respiratory Medicine, Gentofte Hospital, University of Copenhagen, 27709 Copenhagen, DenmarkDepartment of Radiology, Vancouver General Hospital and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, V5Z 1M9, CanadaDepartment of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, NorwayCenter of Expertise for Chronic Organ Failure (Ciro), 6085 NM Horn, The NetherlandsDepartment of Thoracic Medicine, Haukeland University Hospital, 5021 Bergen, NorwayThe objective of the present study was to determine the association between CT phenotypes—emphysema by low attenuation area and bronchitis by airway wall thickness—and body composition parameters in a large cohort of subjects with and without COPD. In 452 COPD subjects and 459 subjects without COPD, CT scans were performed to determine emphysema (%LAA), airway wall thickness (AWT-Pi10), and lung mass. Muscle wasting based on FFMI was assessed by bioelectrical impedance. In both the men and women with COPD, FFMI was negatively associated with %LAA. FMI was positively associated with AWT-Pi10 in both subjects with and without COPD. Among the subjects with muscle wasting, the percentage emphysema was high, but the predictive value was moderate. In conclusion, the present study strengthens the hypothesis that the subgroup of COPD cases with muscle wasting have emphysema. Airway wall thickness is positively associated with fat mass index in both subjects with and without COPD.http://dx.doi.org/10.1155/2011/419328 |
| spellingShingle | Erica P. A. Rutten Thomas B. Grydeland Sreekumar G. Pillai Scott Wagers Asger Dirksen Harvey O. Coxson Amund Gulsvik Emiel F. M. Wouters Per S. Bakke Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD Pulmonary Medicine |
| title | Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD |
| title_full | Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD |
| title_fullStr | Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD |
| title_full_unstemmed | Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD |
| title_short | Quantitative CT: Associations between Emphysema, Airway Wall Thickness and Body Composition in COPD |
| title_sort | quantitative ct associations between emphysema airway wall thickness and body composition in copd |
| url | http://dx.doi.org/10.1155/2011/419328 |
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