Modulation of Brain Kynurenic Acid by N-Acetylcysteine Prevents Cognitive Impairment and Muscular Weakness Induced by Cisplatin in Female Rats

Modulation of Brain Kynurenic Acid by N-Acetylcysteine Prevents Cognitive Impairment and Muscular Weakness Induced by Cisplatin in Female Rats

Cisplatin (CIS) is a potent chemotherapeutic agent primarily used to treat hematologic malignancies and solid tumors, including lymphomas, sarcomas, and some carcinomas. Patients receiving this treatment for tumors outside the nervous system develop cognitive impairment. Alterations in the kynurenin...

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Main Authors: Teminijesu Dorcas Aremu, Daniela Ramírez Ortega, Tonali Blanco Ayala, Dinora Fabiola González Esquivel, Benjamín Pineda, Gonzalo Pérez de la Cruz, Alelí Salazar, Itamar Flores, Karla F. Meza-Sosa, Laura Sánchez Chapul, Edgar Rangel-López, Saúl Gómez-Manzo, Adrián Márquez Navarro, Gabriel Roldán Roldán, Verónica Pérez de la Cruz
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
chemo-brain
cognitive impairment
kynurenic acid
redox environment
Online Access:https://www.mdpi.com/2073-4409/13/23/1989
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