Role of Lactate in Inflammatory Processes: Friend or Foe
During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in glycolysis. In recent years, evidence has accumu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.808799/full |
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| author | Carolina Manosalva John Quiroga John Quiroga Alejandra I. Hidalgo Pablo Alarcón Nicolás Ansoleaga Nicolás Ansoleaga María Angélica Hidalgo Rafael Agustín Burgos |
| author_facet | Carolina Manosalva John Quiroga John Quiroga Alejandra I. Hidalgo Pablo Alarcón Nicolás Ansoleaga Nicolás Ansoleaga María Angélica Hidalgo Rafael Agustín Burgos |
| author_sort | Carolina Manosalva |
| collection | DOAJ |
| description | During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in glycolysis. In recent years, evidence has accumulated describing the role of lactate in inflammatory processes; however, there are differences as to whether lactate can currently be considered a pro- or anti-inflammatory mediator. Herein, we review these recent advances on the pleiotropic effects of lactate on the inflammatory process. Taken together, the evidence suggests that lactate could exert differential effects depending on the metabolic status, cell type in which the effects of lactate are studied, and the pathological process analyzed. Additionally, various targets, including post-translational modifications, G-protein coupled receptor and transcription factor activation such as NF-κB and HIF-1, allow lactate to modulate signaling pathways that control the expression of cytokines, chemokines, adhesion molecules, and several enzymes associated with immune response and metabolism. Altogether, this would explain its varied effects on inflammatory processes beyond its well-known role as a waste product of metabolism. |
| format | Article |
| id | doaj-art-e187bb2125e743c2a549f7ca7af197cb |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e187bb2125e743c2a549f7ca7af197cb2025-01-27T08:55:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.808799808799Role of Lactate in Inflammatory Processes: Friend or FoeCarolina Manosalva0John Quiroga1John Quiroga2Alejandra I. Hidalgo3Pablo Alarcón4Nicolás Ansoleaga5Nicolás Ansoleaga6María Angélica Hidalgo7Rafael Agustín Burgos8Faculty of Sciences, Institute of Pharmacy, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileGraduate School, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileGraduate School, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileLaboratory of Immunometabolism, Faculty of Veterinary Sciences, Institute of Pharmacology and Morphophysiology, Universidad Austral de Chile, Valdivia, ChileDuring an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH drop in the inflamed tissue is largely attributed to the presence of lactate by an increase in glycolysis. In recent years, evidence has accumulated describing the role of lactate in inflammatory processes; however, there are differences as to whether lactate can currently be considered a pro- or anti-inflammatory mediator. Herein, we review these recent advances on the pleiotropic effects of lactate on the inflammatory process. Taken together, the evidence suggests that lactate could exert differential effects depending on the metabolic status, cell type in which the effects of lactate are studied, and the pathological process analyzed. Additionally, various targets, including post-translational modifications, G-protein coupled receptor and transcription factor activation such as NF-κB and HIF-1, allow lactate to modulate signaling pathways that control the expression of cytokines, chemokines, adhesion molecules, and several enzymes associated with immune response and metabolism. Altogether, this would explain its varied effects on inflammatory processes beyond its well-known role as a waste product of metabolism.https://www.frontiersin.org/articles/10.3389/fimmu.2021.808799/fulllactateinflammationG-protein coupled receptorsimmunometabolismmonocarboxylate transport |
| spellingShingle | Carolina Manosalva John Quiroga John Quiroga Alejandra I. Hidalgo Pablo Alarcón Nicolás Ansoleaga Nicolás Ansoleaga María Angélica Hidalgo Rafael Agustín Burgos Role of Lactate in Inflammatory Processes: Friend or Foe Frontiers in Immunology lactate inflammation G-protein coupled receptors immunometabolism monocarboxylate transport |
| title | Role of Lactate in Inflammatory Processes: Friend or Foe |
| title_full | Role of Lactate in Inflammatory Processes: Friend or Foe |
| title_fullStr | Role of Lactate in Inflammatory Processes: Friend or Foe |
| title_full_unstemmed | Role of Lactate in Inflammatory Processes: Friend or Foe |
| title_short | Role of Lactate in Inflammatory Processes: Friend or Foe |
| title_sort | role of lactate in inflammatory processes friend or foe |
| topic | lactate inflammation G-protein coupled receptors immunometabolism monocarboxylate transport |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.808799/full |
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