Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization
Reduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The present study was aimed to investigate whether this type of maternal malnutrition...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2008/646919 |
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| author | Alejandro Hernández Héctor Burgos Mauricio Mondaca Rafael Barra Héctor Núñez Hernán Pérez Rubén Soto-Moyano Walter Sierralta Victor Fernández Ricardo Olivares Luis Valladares |
| author_facet | Alejandro Hernández Héctor Burgos Mauricio Mondaca Rafael Barra Héctor Núñez Hernán Pérez Rubén Soto-Moyano Walter Sierralta Victor Fernández Ricardo Olivares Luis Valladares |
| author_sort | Alejandro Hernández |
| collection | DOAJ |
| description | Reduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The present study was aimed to investigate whether this type of maternal malnutrition could result in modification of plastic capabilities of the entorhinal cortex (EC) in the adult progeny. Unlike normal eutrophic controls, 55–60-day-old prenatally malnourished rats were unable to develop LTP in the medial EC to tetanizing stimulation delivered to either the ipsilateral occipital cortex or the CA1 hippocampal region. Tetanizing stimulation of CA1 also failed to increase the concentration of brain-derived neurotrophic factor (BDNF) in the EC of malnourished rats. Impaired capacity of the EC of prenatally malnourished rats to develop LTP and to increase BDNF levels during adulthood may be an important factor contributing to deficits in learning performance having adult prenatally malnourished animals. |
| format | Article |
| id | doaj-art-e1857dd45cf546aeb97d75a43461f535 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e1857dd45cf546aeb97d75a43461f5352025-02-03T01:12:16ZengWileyNeural Plasticity2090-59041687-54432008-01-01200810.1155/2008/646919646919Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal TetanizationAlejandro Hernández0Héctor Burgos1Mauricio Mondaca2Rafael Barra3Héctor Núñez4Hernán Pérez5Rubén Soto-Moyano6Walter Sierralta7Victor Fernández8Ricardo Olivares9Luis Valladares10Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, 3363 Avenida Alameda Bernardo O'Higgins, 9170022 Santiago, ChileSchool of Psychology, Las Americas University, 1 Oriente Mall Marina Arauco, 2541362 Viña del Mar, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileMontessori Study Center, 2865 Avenida Duble Alméyda, 7750169 Santiago, ChileDepartment of Animal Biological Sciences, Faculty of Veterinary Sciences, University of Chile, 11735 Avenida Santa Rosa, 8820808 Santiago, ChileInstitute of Nutrition and Food Technology (INTA), University of Chile, 5540 Avenida Macul, 7830489 Santiago, ChileReduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The present study was aimed to investigate whether this type of maternal malnutrition could result in modification of plastic capabilities of the entorhinal cortex (EC) in the adult progeny. Unlike normal eutrophic controls, 55–60-day-old prenatally malnourished rats were unable to develop LTP in the medial EC to tetanizing stimulation delivered to either the ipsilateral occipital cortex or the CA1 hippocampal region. Tetanizing stimulation of CA1 also failed to increase the concentration of brain-derived neurotrophic factor (BDNF) in the EC of malnourished rats. Impaired capacity of the EC of prenatally malnourished rats to develop LTP and to increase BDNF levels during adulthood may be an important factor contributing to deficits in learning performance having adult prenatally malnourished animals.http://dx.doi.org/10.1155/2008/646919 |
| spellingShingle | Alejandro Hernández Héctor Burgos Mauricio Mondaca Rafael Barra Héctor Núñez Hernán Pérez Rubén Soto-Moyano Walter Sierralta Victor Fernández Ricardo Olivares Luis Valladares Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization Neural Plasticity |
| title | Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization |
| title_full | Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization |
| title_fullStr | Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization |
| title_full_unstemmed | Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization |
| title_short | Effect of Prenatal Protein Malnutrition on Long-Term Potentiation and BDNF Protein Expression in the Rat Entorhinal Cortex after Neocortical and Hippocampal Tetanization |
| title_sort | effect of prenatal protein malnutrition on long term potentiation and bdnf protein expression in the rat entorhinal cortex after neocortical and hippocampal tetanization |
| url | http://dx.doi.org/10.1155/2008/646919 |
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