Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides
In this paper, the antihypertension effect of rice peptide (RP) was studied. With spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) as the research objects, RP disposable gastric and long-term gastric irrigation experiments were carried out and systolic blood pressure (SBP) was measured....
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2022-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000945 |
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| author | Jingjing Dong Shen Wang Xiaoyao Yin Min Fang Zhiyong Gong Yongning Wu |
| author_facet | Jingjing Dong Shen Wang Xiaoyao Yin Min Fang Zhiyong Gong Yongning Wu |
| author_sort | Jingjing Dong |
| collection | DOAJ |
| description | In this paper, the antihypertension effect of rice peptide (RP) was studied. With spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) as the research objects, RP disposable gastric and long-term gastric irrigation experiments were carried out and systolic blood pressure (SBP) was measured. At the end of the long-term gastric irrigation experiment, the content of nitric oxide (NO), angiotensin-converting enzyme (ACE), angiotensin II (Ang II) and renin in the plasma and the activity of ACE were determined. The results showed that RP could reduce systolic pressure of SHR and had time-dose dependence while high-dose RP significantly reduced systolic pressure by 24.6 and 17.2 mmHg, respectively after a single and long-term gastric irrigation test. RP also could inhibit the activity of ACE and increase the release of NO. These results suggested that the decompression mechanism of RP is likely to be related to the regulation of the renin-angiotensin system (RAS) and NO. |
| format | Article |
| id | doaj-art-e17f001327be40d283086c7356e93988 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-e17f001327be40d283086c7356e939882025-02-03T03:59:54ZengTsinghua University PressFood Science and Human Wellness2213-45302022-11-0111615391543Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptidesJingjing Dong0Shen Wang1Xiaoyao Yin2Min Fang3Zhiyong Gong4Yongning Wu5Key Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, ChinaKey Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, ChinaKey Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, ChinaKey Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, ChinaKey Laboratory for Deep Processing of Major Grain and Oil of Ministry of Education, College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China; Corresponding author at: College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China.HC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, ChinaIn this paper, the antihypertension effect of rice peptide (RP) was studied. With spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) as the research objects, RP disposable gastric and long-term gastric irrigation experiments were carried out and systolic blood pressure (SBP) was measured. At the end of the long-term gastric irrigation experiment, the content of nitric oxide (NO), angiotensin-converting enzyme (ACE), angiotensin II (Ang II) and renin in the plasma and the activity of ACE were determined. The results showed that RP could reduce systolic pressure of SHR and had time-dose dependence while high-dose RP significantly reduced systolic pressure by 24.6 and 17.2 mmHg, respectively after a single and long-term gastric irrigation test. RP also could inhibit the activity of ACE and increase the release of NO. These results suggested that the decompression mechanism of RP is likely to be related to the regulation of the renin-angiotensin system (RAS) and NO.http://www.sciencedirect.com/science/article/pii/S2213453022000945Rice peptideAngiotensin-converting enzyme (ACE)Antihypertensive effect |
| spellingShingle | Jingjing Dong Shen Wang Xiaoyao Yin Min Fang Zhiyong Gong Yongning Wu Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides Food Science and Human Wellness Rice peptide Angiotensin-converting enzyme (ACE) Antihypertensive effect |
| title | Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides |
| title_full | Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides |
| title_fullStr | Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides |
| title_full_unstemmed | Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides |
| title_short | Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects of rice peptides |
| title_sort | angiotensin i converting enzyme ace inhibitory activity and antihypertensive effects of rice peptides |
| topic | Rice peptide Angiotensin-converting enzyme (ACE) Antihypertensive effect |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022000945 |
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