Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

Summary: Sirtuin-1 (SIRT1) is a classical histone deacetylase well known for its roles in intracellular pathways such as energy metabolism, DNA damage response, and genome stability maintenance. We report that SIRT1 can be secreted into the tumor microenvironment (TME) through an unconventional prot...

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Bibliographic Details
Main Authors: Zhuo Wang, Wendong Guo, Xiaowen Zhang, Yufei Wei, Wanying Zhang, Ning Du, Chunlu Li, Xuan Wu, Fei Yi, Tingting Zhou, Xiang Dong, Qiqiang Guo, Hongde Xu, Erli Wang, Na Li, Rong Cheng, Ziwei Li, Xiaoyu Song, Yingxian Sun, Xun Sun, Liu Cao
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004504
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