Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy
Breast cancer (BC) is the most prevalent malignancy in women. The emergence of targeted therapies and advancements in comprehensive treatment protocols have significantly improved survival outcomes for patients with early-stage BC. However, individuals with refractory BC, particularly those who have...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-08-01
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| Series: | Breast Cancer: Basic and Clinical Research |
| Online Access: | https://doi.org/10.1177/11782234251365941 |
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| _version_ | 1849390231948623872 |
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| author | Cunjun Mai Huiyang Tang Guie Lai Lulin Liu Wenzhen Huang Kang He Qingyang Liu You Sun Dongmin Yu |
| author_facet | Cunjun Mai Huiyang Tang Guie Lai Lulin Liu Wenzhen Huang Kang He Qingyang Liu You Sun Dongmin Yu |
| author_sort | Cunjun Mai |
| collection | DOAJ |
| description | Breast cancer (BC) is the most prevalent malignancy in women. The emergence of targeted therapies and advancements in comprehensive treatment protocols have significantly improved survival outcomes for patients with early-stage BC. However, individuals with refractory BC, particularly those who have received multiple lines of therapy or presented with distant metastases at diagnosis, continue to face challenges due to the limitations of conventional antibodies and cytotoxic agents in meeting therapeutic needs. Thus, the development of novel and effective treatments for BC, along with strategies to prevent recurrence, remains an urgent priority. Research has shown that nanodrug delivery systems can modify the pharmacokinetic profiles of traditional chemotherapeutic agents, thereby markedly reducing adverse drug reactions. Furthermore, studies have demonstrated that innovative approaches, such as hyaluronic acid-based systems, ultrasound-mediated microbubbles, and antibody-drug conjugates (ADCs), enable targeted and controlled drug release, offering advantages including high drug efficacy, reduced toxicity, and significant antitumor effects. Among these, ADCs have gained increasing attention in BC therapy over recent years. This article provides a comprehensive review of the development and progress of various drug delivery systems in BC treatment, offering an in-depth analysis of their potential applications in clinical practice. |
| format | Article |
| id | doaj-art-e17b1635047a4a4e9e7fd5b77e14df99 |
| institution | Kabale University |
| issn | 1178-2234 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Breast Cancer: Basic and Clinical Research |
| spelling | doaj-art-e17b1635047a4a4e9e7fd5b77e14df992025-08-20T03:41:43ZengSAGE PublishingBreast Cancer: Basic and Clinical Research1178-22342025-08-011910.1177/11782234251365941Prospects and Challenges of Different Delivery Systems in Breast Tumors TherapyCunjun Mai0Huiyang Tang1Guie Lai2Lulin Liu3Wenzhen Huang4Kang He5Qingyang Liu6You Sun7Dongmin Yu8Department of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Breast Disease Comprehensive Center, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First Clinical Medical College, Gannan Medical University, Ganzhou, ChinaJiangxi Provincial Key Laboratory of Tissue Engineering, Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, ChinaGanzhou Key Laboratory of Osteoporosis Research, Ganzhou, ChinaBreast cancer (BC) is the most prevalent malignancy in women. The emergence of targeted therapies and advancements in comprehensive treatment protocols have significantly improved survival outcomes for patients with early-stage BC. However, individuals with refractory BC, particularly those who have received multiple lines of therapy or presented with distant metastases at diagnosis, continue to face challenges due to the limitations of conventional antibodies and cytotoxic agents in meeting therapeutic needs. Thus, the development of novel and effective treatments for BC, along with strategies to prevent recurrence, remains an urgent priority. Research has shown that nanodrug delivery systems can modify the pharmacokinetic profiles of traditional chemotherapeutic agents, thereby markedly reducing adverse drug reactions. Furthermore, studies have demonstrated that innovative approaches, such as hyaluronic acid-based systems, ultrasound-mediated microbubbles, and antibody-drug conjugates (ADCs), enable targeted and controlled drug release, offering advantages including high drug efficacy, reduced toxicity, and significant antitumor effects. Among these, ADCs have gained increasing attention in BC therapy over recent years. This article provides a comprehensive review of the development and progress of various drug delivery systems in BC treatment, offering an in-depth analysis of their potential applications in clinical practice.https://doi.org/10.1177/11782234251365941 |
| spellingShingle | Cunjun Mai Huiyang Tang Guie Lai Lulin Liu Wenzhen Huang Kang He Qingyang Liu You Sun Dongmin Yu Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy Breast Cancer: Basic and Clinical Research |
| title | Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy |
| title_full | Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy |
| title_fullStr | Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy |
| title_full_unstemmed | Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy |
| title_short | Prospects and Challenges of Different Delivery Systems in Breast Tumors Therapy |
| title_sort | prospects and challenges of different delivery systems in breast tumors therapy |
| url | https://doi.org/10.1177/11782234251365941 |
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