Detection assay of polymyxin resistance coding mcr-1 gene based on CRISPR/Cas13a system

Detection assay of polymyxin resistance coding mcr-1 gene based on CRISPR/Cas13a system

IntroductionPolymyxins are reserved as an ultimate defense against multidrug-resistant bacteria. The emergence of the polymyxin resistance gene mcr-1 poses a potential risk for the treatment of severe infections caused by Gram-negative bacteria. Timely detection and monitoring the mcr-1 gene are ess...

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Bibliographic Details
Main Authors: Yingjie Song, Qiang Hu, Yao Han, Hongbo Liu, Zhenyang Huang, Mengwei Niu, Xue Dong, Kuocheng Yan, Li Jin, Hao Li, Yansong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
mcr-1
polymyxin
antibiotic resistance
CRISPR/Cas13a
lateral flow strip
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1553681/full
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