Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B
Cell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division. To date, there is no study to investigate IFNα therapy on hTERT mRNA expression in PBMCs...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/920146 |
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| author | Chuan-wu Zhu Ming Chen Xiang-rong Luo Hai-yan Wang Li-hua Wang Jian-hong Wu Ming Li Xue-hua Zhang Wei Zhu Jian-zhong Ye Feng Qian |
| author_facet | Chuan-wu Zhu Ming Chen Xiang-rong Luo Hai-yan Wang Li-hua Wang Jian-hong Wu Ming Li Xue-hua Zhang Wei Zhu Jian-zhong Ye Feng Qian |
| author_sort | Chuan-wu Zhu |
| collection | DOAJ |
| description | Cell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division. To date, there is no study to investigate IFNα therapy on hTERT mRNA expression in PBMCs of patients with chronic hepatitis B (CHB). We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized (NhTERT mRNA). Mean NhTERT mRNA level was lower in either CHB group, but it significantly increased in IFNα-treated group compared with CHB control group, and a longer duration of IFNα therapy could increase the level. Moreover, the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without. NhTERT mRNA was markedly correlated with CD3+ T lymphocyte count and CD4+/CD8+ ratio. The results showed that IFNα therapy could upregulate the expression of hTERT mRNA in PBMCs. |
| format | Article |
| id | doaj-art-e16eacc1cee44853afee9b8ceddfd795 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e16eacc1cee44853afee9b8ceddfd7952025-08-20T02:21:01ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/920146920146Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis BChuan-wu Zhu0Ming Chen1Xiang-rong Luo2Hai-yan Wang3Li-hua Wang4Jian-hong Wu5Ming Li6Xue-hua Zhang7Wei Zhu8Jian-zhong Ye9Feng Qian10Department of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Infectious Diseases, Affiliated Hospital of Medical College of Xuzhou, Xuzhou 221000, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Infectious Diseases, Affiliated Hospital of Medical College of Xuzhou, Xuzhou 221000, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaDepartment of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, ChinaCell division is closely related to telomerase activity (hTERT mRNA). Lower expression of lymphocitic hTERT mRNA may easily cause cell aging, which is not beneficial to maintaining a durable lymphocyte division. To date, there is no study to investigate IFNα therapy on hTERT mRNA expression in PBMCs of patients with chronic hepatitis B (CHB). We quantitatively detected hTERT mRNA from study subjects and made each hTERT mRNA normalized (NhTERT mRNA). Mean NhTERT mRNA level was lower in either CHB group, but it significantly increased in IFNα-treated group compared with CHB control group, and a longer duration of IFNα therapy could increase the level. Moreover, the mean NhTERT mRNA in subgroup with HBeAg loss was significantly higher than that in subgroup without. NhTERT mRNA was markedly correlated with CD3+ T lymphocyte count and CD4+/CD8+ ratio. The results showed that IFNα therapy could upregulate the expression of hTERT mRNA in PBMCs.http://dx.doi.org/10.1155/2011/920146 |
| spellingShingle | Chuan-wu Zhu Ming Chen Xiang-rong Luo Hai-yan Wang Li-hua Wang Jian-hong Wu Ming Li Xue-hua Zhang Wei Zhu Jian-zhong Ye Feng Qian Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B Clinical and Developmental Immunology |
| title | Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| title_full | Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| title_fullStr | Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| title_full_unstemmed | Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| title_short | Interferon Alpha on Expression of hTERT mRNA in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis B |
| title_sort | interferon alpha on expression of htert mrna in peripheral blood mononuclear cells of patients with chronic hepatitis b |
| url | http://dx.doi.org/10.1155/2011/920146 |
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