The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study
Aim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT f...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/8825189 |
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| author | Zhi-Ning Ye Harry Hua-Xiang Xia Ran Zhang Lan Li Li-Hao Wu Xu-Juan Liu Wen-Rui Xie Xing-Xiang He |
| author_facet | Zhi-Ning Ye Harry Hua-Xiang Xia Ran Zhang Lan Li Li-Hao Wu Xu-Juan Liu Wen-Rui Xie Xing-Xiang He |
| author_sort | Zhi-Ning Ye |
| collection | DOAJ |
| description | Aim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT for various indications and who were positive for H. pylori infection before WMT treatment but had never received eradication therapy for H. pylori infection were invited to take a follow-up 13C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined. Results. A total of 32 eligible patients were included, and the overall H. pylori eradication rate was 40.6% (13/32). Patients with H. pylori eradication had a higher pepsinogen ratio (PGR) than those without (13.00±6.97vs.8.31±3.733; P=0.02). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% vs. 31.58%; P=0.208). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of H. pylori infection (58.33% vs 16.67%; P=0.152). There was no significant difference in other demographic and clinical factors between patients with and without H. pylori eradication. Conclusion. H. pylori infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials. |
| format | Article |
| id | doaj-art-e16b07eddf9d4446bdf1bff562f82b83 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e16b07eddf9d4446bdf1bff562f82b832025-08-20T02:21:01ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/88251898825189The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot StudyZhi-Ning Ye0Harry Hua-Xiang Xia1Ran Zhang2Lan Li3Li-Hao Wu4Xu-Juan Liu5Wen-Rui Xie6Xing-Xiang He7Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, ChinaAim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT for various indications and who were positive for H. pylori infection before WMT treatment but had never received eradication therapy for H. pylori infection were invited to take a follow-up 13C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined. Results. A total of 32 eligible patients were included, and the overall H. pylori eradication rate was 40.6% (13/32). Patients with H. pylori eradication had a higher pepsinogen ratio (PGR) than those without (13.00±6.97vs.8.31±3.733; P=0.02). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% vs. 31.58%; P=0.208). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of H. pylori infection (58.33% vs 16.67%; P=0.152). There was no significant difference in other demographic and clinical factors between patients with and without H. pylori eradication. Conclusion. H. pylori infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials.http://dx.doi.org/10.1155/2020/8825189 |
| spellingShingle | Zhi-Ning Ye Harry Hua-Xiang Xia Ran Zhang Lan Li Li-Hao Wu Xu-Juan Liu Wen-Rui Xie Xing-Xiang He The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study Gastroenterology Research and Practice |
| title | The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study |
| title_full | The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study |
| title_fullStr | The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study |
| title_full_unstemmed | The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study |
| title_short | The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study |
| title_sort | efficacy of washed microbiota transplantation on helicobacter pylori eradication a pilot study |
| url | http://dx.doi.org/10.1155/2020/8825189 |
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