A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis
Malignant changes in endometriosis are often reported, but those in adenomyosis are rare. We report a case of endometrioid adenocarcinoma arising from adenomyosis. Case Presentation. A 57-year-old woman presenting with vaginal bleeding was referred to our hospital. Cytological tests of endometrium r...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2014/569295 |
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| author | Shigeki Taga Mari Sawada Aya Nagai Dan Yamamoto Ryoji Hayase |
| author_facet | Shigeki Taga Mari Sawada Aya Nagai Dan Yamamoto Ryoji Hayase |
| author_sort | Shigeki Taga |
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| description | Malignant changes in endometriosis are often reported, but those in adenomyosis are rare. We report a case of endometrioid adenocarcinoma arising from adenomyosis. Case Presentation. A 57-year-old woman presenting with vaginal bleeding was referred to our hospital. Cytological tests of endometrium revealed atypical glandular cells. Fractional endometrial curettage revealed normal endometrium without atypia. Magnetic resonance imaging (MRI) revealed multiple myomas. The endometrium was slightly enhanced on T1-weighted imaging and endometrial cancer was suspected. Myometrial invasion was not evident. The patient was admitted and semiradical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. Histopathological study revealed grade 1 endometrioid adenocarcinoma. Although the lesion was located in the muscle layer of the corpus and invaded more than half of it, the endometrium was intact. Pelvic lymph node metastasis was noticed. No cervical invasion or metastasis to the adnexa was seen. We diagnosed the case with a stage 1B endometrioid adenocarcinoma originating from adenomyosis. Adjuvant chemotherapy was then performed in the form of 5 cycles of paclitaxel (180 mg/m2) and carboplatin (AUC = 5). Five years later, right lung metastasis and right para-aortic and pelvic lymph nodes metastasis were noticed. Paclitaxel and carboplatin are now being administered. |
| format | Article |
| id | doaj-art-e167f47f9ccd4a92a2c85e69f95ad6cd |
| institution | OA Journals |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-e167f47f9ccd4a92a2c85e69f95ad6cd2025-08-20T02:21:01ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922014-01-01201410.1155/2014/569295569295A Case of Endometrioid Adenocarcinoma Arising from AdenomyosisShigeki Taga0Mari Sawada1Aya Nagai2Dan Yamamoto3Ryoji Hayase4Department of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Okinogamicho 4-14-17, Fukuyama 720-0825, Hiroshima Prefecture, JapanDepartment of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Okinogamicho 4-14-17, Fukuyama 720-0825, Hiroshima Prefecture, JapanDepartment of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Okinogamicho 4-14-17, Fukuyama 720-0825, Hiroshima Prefecture, JapanDepartment of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Okinogamicho 4-14-17, Fukuyama 720-0825, Hiroshima Prefecture, JapanDepartment of Obstetrics and Gynecology, National Hospital Organization Fukuyama Medical Center, Okinogamicho 4-14-17, Fukuyama 720-0825, Hiroshima Prefecture, JapanMalignant changes in endometriosis are often reported, but those in adenomyosis are rare. We report a case of endometrioid adenocarcinoma arising from adenomyosis. Case Presentation. A 57-year-old woman presenting with vaginal bleeding was referred to our hospital. Cytological tests of endometrium revealed atypical glandular cells. Fractional endometrial curettage revealed normal endometrium without atypia. Magnetic resonance imaging (MRI) revealed multiple myomas. The endometrium was slightly enhanced on T1-weighted imaging and endometrial cancer was suspected. Myometrial invasion was not evident. The patient was admitted and semiradical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. Histopathological study revealed grade 1 endometrioid adenocarcinoma. Although the lesion was located in the muscle layer of the corpus and invaded more than half of it, the endometrium was intact. Pelvic lymph node metastasis was noticed. No cervical invasion or metastasis to the adnexa was seen. We diagnosed the case with a stage 1B endometrioid adenocarcinoma originating from adenomyosis. Adjuvant chemotherapy was then performed in the form of 5 cycles of paclitaxel (180 mg/m2) and carboplatin (AUC = 5). Five years later, right lung metastasis and right para-aortic and pelvic lymph nodes metastasis were noticed. Paclitaxel and carboplatin are now being administered.http://dx.doi.org/10.1155/2014/569295 |
| spellingShingle | Shigeki Taga Mari Sawada Aya Nagai Dan Yamamoto Ryoji Hayase A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis Case Reports in Obstetrics and Gynecology |
| title | A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis |
| title_full | A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis |
| title_fullStr | A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis |
| title_full_unstemmed | A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis |
| title_short | A Case of Endometrioid Adenocarcinoma Arising from Adenomyosis |
| title_sort | case of endometrioid adenocarcinoma arising from adenomyosis |
| url | http://dx.doi.org/10.1155/2014/569295 |
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