Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer
Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer. Methods: Patients scheduled to receive...
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Elsevier
2025-01-01
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| author | Mitchell S. von Itzstein, MD Jialiang Liu, PhD Hong Mu-Mosley, PhD Farjana Fattah, PhD Jason Y. Park, MD, PhD Jeffrey A. SoRelle, MD J. David Farrar, PhD Mary E. Gwin, MD David Hsiehchen, MD Yvonne Gloria-McCutchen Edward K. Wakeland, PhD Suzanne Cole, MD Sheena Bhalla, MD Radhika Kainthla, MD Igor Puzanov, MD, MSCI Benjamin Switzer, DO, MHSA, MS Gregory A. Daniels, MD, PhD Yousef Zakharia, MD Montaser Shaheen, MD Jianjun Zhang, MD, PhD Yang Xie, PhD David E. Gerber, MD |
| author_facet | Mitchell S. von Itzstein, MD Jialiang Liu, PhD Hong Mu-Mosley, PhD Farjana Fattah, PhD Jason Y. Park, MD, PhD Jeffrey A. SoRelle, MD J. David Farrar, PhD Mary E. Gwin, MD David Hsiehchen, MD Yvonne Gloria-McCutchen Edward K. Wakeland, PhD Suzanne Cole, MD Sheena Bhalla, MD Radhika Kainthla, MD Igor Puzanov, MD, MSCI Benjamin Switzer, DO, MHSA, MS Gregory A. Daniels, MD, PhD Yousef Zakharia, MD Montaser Shaheen, MD Jianjun Zhang, MD, PhD Yang Xie, PhD David E. Gerber, MD |
| author_sort | Mitchell S. von Itzstein, MD |
| collection | DOAJ |
| description | Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer. Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. Clinical and demographic information were obtained from electronic medical records. Pretreatment peripheral blood samples were collected and analyzed for cytokines using a multiplex panel and for immune cell populations using mass cytometry. Differences between Black and White patients were determined and corrected for multiple comparisons. Results: A total of 187 patients with NSCLC (Black, 19; White, 168) were included in the analysis. Compared with White patients, Black patients had greater comorbidity (median Charlson Comorbidity Index 5 versus 3; p = 0.04) and were more likely to have received previous chemotherapy (79% versus 47%; p = 0.03). Black patients had significantly lower levels of CCL23 and CCL27 and significantly higher levels of CCL8, CXCL1, CCL26, CCL25, CCL1, IL-1b, CXCL16, and IFN-γ (all p < 0.05, false discovery rate < 0.1). Black patients also exhibited greater populations of nonclassical CD16+ monocytes, NKT-like cells, CD4+ cells, CD38+ monocytes, and CD57+ gamma delta T cells (all p < 0.05). Conclusions: Black and White patients with lung cancer exhibit several differences in immune parameters, with Black patients exhibiting greater levels of numerous proinflammatory cytokines and cell populations. The etiology and clinical significance of these differences warrant further evaluation. |
| format | Article |
| id | doaj-art-e166f0b2862d482b95a71942e6dcb113 |
| institution | Kabale University |
| issn | 2666-3643 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj-art-e166f0b2862d482b95a71942e6dcb1132025-01-20T04:17:53ZengElsevierJTO Clinical and Research Reports2666-36432025-01-0161100751Racial Differences in Systemic Immune Parameters in Individuals With Lung CancerMitchell S. von Itzstein, MD0Jialiang Liu, PhD1Hong Mu-Mosley, PhD2Farjana Fattah, PhD3Jason Y. Park, MD, PhD4Jeffrey A. SoRelle, MD5J. David Farrar, PhD6Mary E. Gwin, MD7David Hsiehchen, MD8Yvonne Gloria-McCutchen9Edward K. Wakeland, PhD10Suzanne Cole, MD11Sheena Bhalla, MD12Radhika Kainthla, MD13Igor Puzanov, MD, MSCI14Benjamin Switzer, DO, MHSA, MS15Gregory A. Daniels, MD, PhD16Yousef Zakharia, MD17Montaser Shaheen, MD18Jianjun Zhang, MD, PhD19Yang Xie, PhD20David E. Gerber, MD21Department of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TexasHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Immunology, University of Texas Southwestern Medical Center. Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Immunology, University of Texas Southwestern Medical Center. Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TexasRoswell Park Comprehensive Cancer Center, Buffalo, New YorkRoswell Park Comprehensive Cancer Center, Buffalo, New YorkMoores Cancer Center, University of California San Diego Health, San Diego, CaliforniaUniversity of Iowa Hospitals and Clinics, Iowa City, IowaUniversity of Texas Health Science Center, San Antonio, TexasMD Anderson Cancer Center, Houston, TexasQuantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas; Peter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Internal Medicine (Division of Hematology-Oncology), University of Texas Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Peter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas; Corresponding author. Address for correspondence: David E. Gerber, MD, Division of Hematology-Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Mail Code 8852, Dallas, Texas 75390-8852.Introduction: Racial and ethnic disparities in the presentation and outcomes of lung cancer are widely known. To evaluate potential factors contributing to these observations, we measured systemic immune parameters in Black and White patients with lung cancer. Methods: Patients scheduled to receive cancer immunotherapy were enrolled in a multi-institutional prospective biospecimen collection registry. Clinical and demographic information were obtained from electronic medical records. Pretreatment peripheral blood samples were collected and analyzed for cytokines using a multiplex panel and for immune cell populations using mass cytometry. Differences between Black and White patients were determined and corrected for multiple comparisons. Results: A total of 187 patients with NSCLC (Black, 19; White, 168) were included in the analysis. Compared with White patients, Black patients had greater comorbidity (median Charlson Comorbidity Index 5 versus 3; p = 0.04) and were more likely to have received previous chemotherapy (79% versus 47%; p = 0.03). Black patients had significantly lower levels of CCL23 and CCL27 and significantly higher levels of CCL8, CXCL1, CCL26, CCL25, CCL1, IL-1b, CXCL16, and IFN-γ (all p < 0.05, false discovery rate < 0.1). Black patients also exhibited greater populations of nonclassical CD16+ monocytes, NKT-like cells, CD4+ cells, CD38+ monocytes, and CD57+ gamma delta T cells (all p < 0.05). Conclusions: Black and White patients with lung cancer exhibit several differences in immune parameters, with Black patients exhibiting greater levels of numerous proinflammatory cytokines and cell populations. The etiology and clinical significance of these differences warrant further evaluation.http://www.sciencedirect.com/science/article/pii/S2666364324001218CytokinesImmune cellsDisparitiesImmunotherapyLung cancerRace |
| spellingShingle | Mitchell S. von Itzstein, MD Jialiang Liu, PhD Hong Mu-Mosley, PhD Farjana Fattah, PhD Jason Y. Park, MD, PhD Jeffrey A. SoRelle, MD J. David Farrar, PhD Mary E. Gwin, MD David Hsiehchen, MD Yvonne Gloria-McCutchen Edward K. Wakeland, PhD Suzanne Cole, MD Sheena Bhalla, MD Radhika Kainthla, MD Igor Puzanov, MD, MSCI Benjamin Switzer, DO, MHSA, MS Gregory A. Daniels, MD, PhD Yousef Zakharia, MD Montaser Shaheen, MD Jianjun Zhang, MD, PhD Yang Xie, PhD David E. Gerber, MD Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer JTO Clinical and Research Reports Cytokines Immune cells Disparities Immunotherapy Lung cancer Race |
| title | Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer |
| title_full | Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer |
| title_fullStr | Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer |
| title_full_unstemmed | Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer |
| title_short | Racial Differences in Systemic Immune Parameters in Individuals With Lung Cancer |
| title_sort | racial differences in systemic immune parameters in individuals with lung cancer |
| topic | Cytokines Immune cells Disparities Immunotherapy Lung cancer Race |
| url | http://www.sciencedirect.com/science/article/pii/S2666364324001218 |
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