Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury

Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway in spinal cord injury

IntroductionFollowing spinal cord injury (SCI), blood-borne monocytes infiltrate the spinal cord, differentiate into macrophages, and dominate the lesion site. Inflammatory responses mediated by macrophages determine nerve regeneration and functional recovery after SCI. Tauroursodeoxycholic acid (TU...

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Bibliographic Details
Main Authors: Yonghui Hou, Yage Zhang, Lin Ma, Dan Luo, Wanshun Wang, Shunmei E., Chengxi Huang, Yu Hou, Shudong Chen, Jiheng Zhan, Liangliang Xu, Dingkun Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
tauroursodeoxycholic acid
spinal cord injury
monocyte
macrophage
microenvironment
nerve regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1554945/full
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