High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy
Abstract Background Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were s...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-024-02222-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585951583404032 |
|---|---|
| author | Meng Zhang Wei Gao Xiaotong Cui Xueting Han Yamei Xu Jingmin Zhou Junbo Ge |
| author_facet | Meng Zhang Wei Gao Xiaotong Cui Xueting Han Yamei Xu Jingmin Zhou Junbo Ge |
| author_sort | Meng Zhang |
| collection | DOAJ |
| description | Abstract Background Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear. Methods We retrospectively screened AHCM patients between January 2019 and December 2021 in Zhongshan Hospital Fudan University. The relationship between the level of hs-cTNT, NT-proBNP and echocardiography parameters were analyzed. The risk factors for elevated hs-cTNT and NT-proBNP level were investigated with linear regression analysis. Results A total of 267 AHCM patients were enrolled. They were divided into hs-cTNT normal (129, 48.3%) and abnormal (138, 51.7%) group. Compared with hs-cTNT normal group, hs-cTNT abnormal group were elder (68.3 ± 11.6 vs. 63.8 ± 10.6, P = 0.001); with higher rate of atrial fibrillation (AF) (41.3% vs. 17.8%, P < 0.001) and higher level of NT-proBNP concentration (752.0 [343.8–1345.5] vs. 249.0 [104.0–541.0], P < 0.001). For echocardiography parameters, hs-cTNT abnormal patients have thicker interventricular septum (IVS) (11.6 ± 2.0 vs. 11.0 ± 1.7, P = 0.02), thicker left ventricular apical (LVA) (16.9 ± 3.0 vs. 14.9 ± 2.3, P < 0.001) and larger left atrium diameter (LAD) (45.9 ± 6.6 vs. 42.4 ± 5.1, P < 0.001). LVA was independently correlated with both the level of hs-cTNT and NT-proBNP (hs-cTNT r = 0.224, P = 0.143; NT-proBNP r = 0.370, P < 0.001). Linear regression analysis revealed that LVA was independent risk factor of both the elevated hs-cTNT and NT-proBNP level. Conclusions More than half of AHCM patients had abnormal hs-cTNT level. LVA was positively and independently correlated with the level of hs-cTNT and NT-proBNP. |
| format | Article |
| id | doaj-art-e165cb76fcbb43849b2f59d408af1470 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-e165cb76fcbb43849b2f59d408af14702025-01-26T12:21:43ZengBMCEuropean Journal of Medical Research2047-783X2025-01-013011710.1186/s40001-024-02222-7High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathyMeng Zhang0Wei Gao1Xiaotong Cui2Xueting Han3Yamei Xu4Jingmin Zhou5Junbo Ge6Department of Cardiology, Zhongshan Hospital, Fudan University (Xiamen Branch)Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular DiseasesAbstract Background Apical hypertrophic cardiomyopathy (AHCM) is a subtype of hypertrophic cardiomyopathy (HCM). The expression level of high-sensitive cardiac troponin T (hs-cTNT) and N-terminal pro-BNP (NT-proBNP) in AHCM patients, and these relationships between echocardiography parameters were still unclear. Methods We retrospectively screened AHCM patients between January 2019 and December 2021 in Zhongshan Hospital Fudan University. The relationship between the level of hs-cTNT, NT-proBNP and echocardiography parameters were analyzed. The risk factors for elevated hs-cTNT and NT-proBNP level were investigated with linear regression analysis. Results A total of 267 AHCM patients were enrolled. They were divided into hs-cTNT normal (129, 48.3%) and abnormal (138, 51.7%) group. Compared with hs-cTNT normal group, hs-cTNT abnormal group were elder (68.3 ± 11.6 vs. 63.8 ± 10.6, P = 0.001); with higher rate of atrial fibrillation (AF) (41.3% vs. 17.8%, P < 0.001) and higher level of NT-proBNP concentration (752.0 [343.8–1345.5] vs. 249.0 [104.0–541.0], P < 0.001). For echocardiography parameters, hs-cTNT abnormal patients have thicker interventricular septum (IVS) (11.6 ± 2.0 vs. 11.0 ± 1.7, P = 0.02), thicker left ventricular apical (LVA) (16.9 ± 3.0 vs. 14.9 ± 2.3, P < 0.001) and larger left atrium diameter (LAD) (45.9 ± 6.6 vs. 42.4 ± 5.1, P < 0.001). LVA was independently correlated with both the level of hs-cTNT and NT-proBNP (hs-cTNT r = 0.224, P = 0.143; NT-proBNP r = 0.370, P < 0.001). Linear regression analysis revealed that LVA was independent risk factor of both the elevated hs-cTNT and NT-proBNP level. Conclusions More than half of AHCM patients had abnormal hs-cTNT level. LVA was positively and independently correlated with the level of hs-cTNT and NT-proBNP.https://doi.org/10.1186/s40001-024-02222-7Apical hypertrophic cardiomyopathyHigh-sensitive cardiac troponin TN-terminal pro-BNPLeft ventricular apical thickness |
| spellingShingle | Meng Zhang Wei Gao Xiaotong Cui Xueting Han Yamei Xu Jingmin Zhou Junbo Ge High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy European Journal of Medical Research Apical hypertrophic cardiomyopathy High-sensitive cardiac troponin T N-terminal pro-BNP Left ventricular apical thickness |
| title | High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| title_full | High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| title_fullStr | High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| title_full_unstemmed | High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| title_short | High-sensitive cardiac troponin T and NT-proBNP are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| title_sort | high sensitive cardiac troponin t and nt probnp are associated with the left ventricular apical thickness in apical hypertrophic cardiomyopathy |
| topic | Apical hypertrophic cardiomyopathy High-sensitive cardiac troponin T N-terminal pro-BNP Left ventricular apical thickness |
| url | https://doi.org/10.1186/s40001-024-02222-7 |
| work_keys_str_mv | AT mengzhang highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT weigao highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT xiaotongcui highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT xuetinghan highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT yameixu highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT jingminzhou highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy AT junboge highsensitivecardiactroponintandntprobnpareassociatedwiththeleftventricularapicalthicknessinapicalhypertrophiccardiomyopathy |