TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

Summary: Cells adapt to nutrient limitation by activating catabolic and inhibiting anabolic pathways, yet prolonged stress may lead to cell death. How cells orchestrate metabolic adaptation and cell death to nutrient stress is poorly understood. We conduct a genome-wide CRISPR-Cas9 screen to identif...

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Bibliographic Details
Main Authors: Wenqing Ren, Hui Jiang, Qianqian Song, Yiliang Chen, Chenxiao Tang, Fang Wang, Jing Zhu, Jingming Ren, Yaxing Zhao, Yuan He, Jin Cai, Tianle Zhang, Zhuhong Wang, Chenjie Zhu, Wen Xue, Ai Peng, Xiaona Feng, Yue Liu, Jianqiang Yu, Zheng-gang Liu, Zhenyu Cai
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500957X
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