Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma
Aims The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesity (AO) interaction with endometrial carcinoma (EC) risk.Methods Hardy–Weinberg equilibrium was te...
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Taylor & Francis Group
2024-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2024.2317270 |
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| author | Wenjuan Tian Siyu Cao Wei Zhang Chenlian Quan Meiqin Zhang Yan Huang |
| author_facet | Wenjuan Tian Siyu Cao Wei Zhang Chenlian Quan Meiqin Zhang Yan Huang |
| author_sort | Wenjuan Tian |
| collection | DOAJ |
| description | Aims The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesity (AO) interaction with endometrial carcinoma (EC) risk.Methods Hardy–Weinberg equilibrium was tested for all participants by using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). The best SNP–SNP and gene–AO interaction combination among three SNPs within XRCC2 gene and AO was screened using generalized multifactor dimensionality reduction (GMDR).Results We employed the logistic regression analysis showed that rs718282-T allele is associated with increased EC risk, adjusted ORs (95%CI) were 1.67 (1.23–2.04). However, we did not find statistical association between rs3218536, and rs3218384 and EC susceptibility. GMDR analysis was used for SNP-SNP- and gene-abdominal obesity analysis. The cross-validation consistency and the testing accuracy for the interaction were calculated. The two-locus model between rs718282 and AO had a testing accuracy of 60.11%, which was significant at the p < .001 level, and this two- locus model was considered as the best model. It provided statistical evidence for rs718282 gene–AO interaction effects. The results indicated that AO influenced the EC risk depending on the rs718282 genotypes. Compared with non- AO subjects with rs718282–CC genotype, AO subjects with rs718282-CT or TT genotype had the highest EC risk, OR (95%CI) was 2.83 (1.67 − 4.02), after covariates adjustment.Conclusions Both the rs718282- T allele, and its interaction with AO were associated with increased EC risk. |
| format | Article |
| id | doaj-art-e155cb4a67e147bfaa2a615cd71f863d |
| institution | DOAJ |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-e155cb4a67e147bfaa2a615cd71f863d2025-08-20T02:39:22ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662024-12-0140110.1080/09513590.2024.2317270Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinomaWenjuan Tian0Siyu Cao1Wei Zhang2Chenlian Quan3Meiqin Zhang4Yan Huang5Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College of Fudan University, Shanghai, ChinaAims The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesity (AO) interaction with endometrial carcinoma (EC) risk.Methods Hardy–Weinberg equilibrium was tested for all participants by using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). The best SNP–SNP and gene–AO interaction combination among three SNPs within XRCC2 gene and AO was screened using generalized multifactor dimensionality reduction (GMDR).Results We employed the logistic regression analysis showed that rs718282-T allele is associated with increased EC risk, adjusted ORs (95%CI) were 1.67 (1.23–2.04). However, we did not find statistical association between rs3218536, and rs3218384 and EC susceptibility. GMDR analysis was used for SNP-SNP- and gene-abdominal obesity analysis. The cross-validation consistency and the testing accuracy for the interaction were calculated. The two-locus model between rs718282 and AO had a testing accuracy of 60.11%, which was significant at the p < .001 level, and this two- locus model was considered as the best model. It provided statistical evidence for rs718282 gene–AO interaction effects. The results indicated that AO influenced the EC risk depending on the rs718282 genotypes. Compared with non- AO subjects with rs718282–CC genotype, AO subjects with rs718282-CT or TT genotype had the highest EC risk, OR (95%CI) was 2.83 (1.67 − 4.02), after covariates adjustment.Conclusions Both the rs718282- T allele, and its interaction with AO were associated with increased EC risk.https://www.tandfonline.com/doi/10.1080/09513590.2024.2317270Abdominal obesityendometrial carcinomainteractionsingle nucleotide polymorphismsX-ray repair cross-complementing group |
| spellingShingle | Wenjuan Tian Siyu Cao Wei Zhang Chenlian Quan Meiqin Zhang Yan Huang Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma Gynecological Endocrinology Abdominal obesity endometrial carcinoma interaction single nucleotide polymorphisms X-ray repair cross-complementing group |
| title | Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| title_full | Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| title_fullStr | Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| title_full_unstemmed | Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| title_short | Interaction between XRCC2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| title_sort | interaction between xrcc2 gene polymorphism and abdominal obesity on risk of endometrial carcinoma |
| topic | Abdominal obesity endometrial carcinoma interaction single nucleotide polymorphisms X-ray repair cross-complementing group |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2024.2317270 |
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