Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients
Background: systemic lupus erythematosus (SLE) is still a challenging autoimmune disease, especially in pregnancy setting. An early risk factors awareness of poor pregnancy outcome is important to optimize the outcome of pregnancy in SLE patients. This study was conducted to describe pregnancy outco...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2019-08-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/697 |
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| author | Laniyati Hamijoyo Januar Wibawa Martha Syarief Hidayat Mohammad Rizki Akbar Henny Tantono Sylvie Sakasasmita Kevin Karim Guntur Darmawan Sasfia Candrianita Erica Kwan Yue Aang Setiawan Budi Setiabudiawan |
| author_facet | Laniyati Hamijoyo Januar Wibawa Martha Syarief Hidayat Mohammad Rizki Akbar Henny Tantono Sylvie Sakasasmita Kevin Karim Guntur Darmawan Sasfia Candrianita Erica Kwan Yue Aang Setiawan Budi Setiabudiawan |
| author_sort | Laniyati Hamijoyo |
| collection | DOAJ |
| description | Background: systemic lupus erythematosus (SLE) is still a challenging autoimmune disease, especially in pregnancy setting. An early risk factors awareness of poor pregnancy outcome is important to optimize the outcome of pregnancy in SLE patients. This study was conducted to describe pregnancy outcome and determine the risk factors associated with poor pregnancy outcome in SLE patients. Methods: a retrospective case-control study of SLE patients with poor and normal pregnancy outcome was performed. Pregnancy histories were reviewed from Dr. Hasan Sadikin General Hospital lupus registry study. The case group was pregnancy with poor outcome, defined as abortion, premature birth, stillbirth, intrauterine growth restriction (IUGR) and neonatal death. The control group was pregnancy with good outcome, defined as live birth and full term. Results: a total of 84 SLE patients were enrolled in this study with 109 pregnancies after SLE diagnosis. The median age of subjects at the time of pregnancy was 28 (25-32) years old. Poor pregnancy outcome comprising 22.9% abortion, 14.7% premature birth, 5.5% stillbirth, 1.8% IUGR and 4.6% neonatal death. There was a significant difference in the number of planned pregnancy (P=0.011) between groups with poor and good outcome. Clinical variables significantly associated with poor pregnancy outcome were lupus nephritis (OR = 4.813, 95% CI 1.709 – 13.557, P = 0.003) and neuropsychiatric SLE (OR = 5.045, 95% CI 1.278 – 19.920, P = 0.021). Conclusion: the pregnancy in SLE patient should be planned to have better outcome. Lupus nephritis and neuropsychiatric (NP) SLE were risk factors for poor pregnancy outcome in SLE patient. |
| format | Article |
| id | doaj-art-e154dd840f3d4340b820645f61c86bbd |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-e154dd840f3d4340b820645f61c86bbd2025-08-20T02:48:12ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322019-08-01512311Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus PatientsLaniyati Hamijoyo0Januar Wibawa Martha1Syarief Hidayat2Mohammad Rizki Akbar3Henny Tantono4Sylvie Sakasasmita5Kevin Karim6Guntur Darmawan7Sasfia Candrianita8Erica Kwan Yue9Aang Setiawan10Budi Setiabudiawan11Rheumatology Division, Department of Internal Medicine Universitas Padjadjaran, Bandung Immunology Study Center, Faculty of MedicineDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, BandungDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, BandungDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, BandungDepartment of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Padjadjaran, BandungImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaImmunology Study Center, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia Department of Pediatric, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia.Background: systemic lupus erythematosus (SLE) is still a challenging autoimmune disease, especially in pregnancy setting. An early risk factors awareness of poor pregnancy outcome is important to optimize the outcome of pregnancy in SLE patients. This study was conducted to describe pregnancy outcome and determine the risk factors associated with poor pregnancy outcome in SLE patients. Methods: a retrospective case-control study of SLE patients with poor and normal pregnancy outcome was performed. Pregnancy histories were reviewed from Dr. Hasan Sadikin General Hospital lupus registry study. The case group was pregnancy with poor outcome, defined as abortion, premature birth, stillbirth, intrauterine growth restriction (IUGR) and neonatal death. The control group was pregnancy with good outcome, defined as live birth and full term. Results: a total of 84 SLE patients were enrolled in this study with 109 pregnancies after SLE diagnosis. The median age of subjects at the time of pregnancy was 28 (25-32) years old. Poor pregnancy outcome comprising 22.9% abortion, 14.7% premature birth, 5.5% stillbirth, 1.8% IUGR and 4.6% neonatal death. There was a significant difference in the number of planned pregnancy (P=0.011) between groups with poor and good outcome. Clinical variables significantly associated with poor pregnancy outcome were lupus nephritis (OR = 4.813, 95% CI 1.709 – 13.557, P = 0.003) and neuropsychiatric SLE (OR = 5.045, 95% CI 1.278 – 19.920, P = 0.021). Conclusion: the pregnancy in SLE patient should be planned to have better outcome. Lupus nephritis and neuropsychiatric (NP) SLE were risk factors for poor pregnancy outcome in SLE patient.https://actamedindones.org/index.php/ijim/article/view/697systemic lupus erythematosuspregnancypoor outcome |
| spellingShingle | Laniyati Hamijoyo Januar Wibawa Martha Syarief Hidayat Mohammad Rizki Akbar Henny Tantono Sylvie Sakasasmita Kevin Karim Guntur Darmawan Sasfia Candrianita Erica Kwan Yue Aang Setiawan Budi Setiabudiawan Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients Acta Medica Indonesiana systemic lupus erythematosus pregnancy poor outcome |
| title | Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients |
| title_full | Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients |
| title_fullStr | Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients |
| title_full_unstemmed | Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients |
| title_short | Risk Factors for Poor Pregnancy Outcome in Systemic Lupus Erythematosus Patients |
| title_sort | risk factors for poor pregnancy outcome in systemic lupus erythematosus patients |
| topic | systemic lupus erythematosus pregnancy poor outcome |
| url | https://actamedindones.org/index.php/ijim/article/view/697 |
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