Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity
Background: This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses. Methods: Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bup...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/sja.sja_810_24 |
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| author | Mevlüt Doğukan Nezir Yılmaz Ahmet Türk Fadime Tosun Mehmet Duran Zeliha Bozkurt |
| author_facet | Mevlüt Doğukan Nezir Yılmaz Ahmet Türk Fadime Tosun Mehmet Duran Zeliha Bozkurt |
| author_sort | Mevlüt Doğukan |
| collection | DOAJ |
| description | Background:
This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.
Methods:
Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.
Results:
The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (P < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.
Conclusion:
ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity. |
| format | Article |
| id | doaj-art-e146128e6cd54d06b50cc29ffb2e9f4a |
| institution | Kabale University |
| issn | 1658-354X 0975-3125 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj-art-e146128e6cd54d06b50cc29ffb2e9f4a2025-08-20T03:29:40ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X0975-31252025-07-0119336336710.4103/sja.sja_810_24Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicityMevlüt DoğukanNezir YılmazAhmet TürkFadime TosunMehmet DuranZeliha BozkurtBackground: This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses. Methods: Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated. Results: The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (P < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D. Conclusion: ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.https://journals.lww.com/10.4103/sja.sja_810_24apoptosisbupivacaineıntravenous lipid emulsionsneuroprotection |
| spellingShingle | Mevlüt Doğukan Nezir Yılmaz Ahmet Türk Fadime Tosun Mehmet Duran Zeliha Bozkurt Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity Saudi Journal of Anaesthesia apoptosis bupivacaine ıntravenous lipid emulsions neuroprotection |
| title | Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity |
| title_full | Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity |
| title_fullStr | Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity |
| title_full_unstemmed | Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity |
| title_short | Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity |
| title_sort | neuroprotective effect of intravenous lipid emulsion after bupivacaine induced cardiac toxicity |
| topic | apoptosis bupivacaine ıntravenous lipid emulsions neuroprotection |
| url | https://journals.lww.com/10.4103/sja.sja_810_24 |
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