Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common respiratory disorder, primarily characterized by two pathological features: chronic intermittent hypoxia (CIH) and sleep deprivation (SD). OSA has been identified as a risk factor for numerous diseases, and the inflammatory response related to programmed cel...
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MDPI AG
2024-10-01
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| author | Jingwen Han Lisong Ye Yan Wang |
| author_facet | Jingwen Han Lisong Ye Yan Wang |
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| description | Obstructive sleep apnea (OSA) is a common respiratory disorder, primarily characterized by two pathological features: chronic intermittent hypoxia (CIH) and sleep deprivation (SD). OSA has been identified as a risk factor for numerous diseases, and the inflammatory response related to programmed cell necrosis is believed to play a significant role in the occurrence and progression of multisystem damage induced by OSA, with increasing attention being paid to pyroptosis. Recent studies have indicated that OSA can elevate oxidative stress levels in the body, activating the process of pyroptosis within different tissues, ultimately accelerating organ dysfunction. However, the molecular mechanisms of pyroptosis in the multisystem damage induced by OSA remain unclear. Therefore, this review focuses on four major systems that have received concentrated attention in existing research in order to explore the role of pyroptosis in promoting renal diseases, cardiovascular diseases, neurocognitive diseases, and skin diseases in OSA patients. Furthermore, we provide a comprehensive overview of methods for inhibiting pyroptosis at different molecular levels, with the goal of identifying viable targets and therapeutic strategies for addressing OSA-related complications. |
| format | Article |
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| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-10-01 |
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| series | Biomolecules |
| spelling | doaj-art-e13704debc3b4f879dd0be4e147d93df2025-08-20T01:53:52ZengMDPI AGBiomolecules2218-273X2024-10-011411134910.3390/biom14111349Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep ApneaJingwen Han0Lisong Ye1Yan Wang2Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, ChinaDepartment of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200001, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai 200001, ChinaObstructive sleep apnea (OSA) is a common respiratory disorder, primarily characterized by two pathological features: chronic intermittent hypoxia (CIH) and sleep deprivation (SD). OSA has been identified as a risk factor for numerous diseases, and the inflammatory response related to programmed cell necrosis is believed to play a significant role in the occurrence and progression of multisystem damage induced by OSA, with increasing attention being paid to pyroptosis. Recent studies have indicated that OSA can elevate oxidative stress levels in the body, activating the process of pyroptosis within different tissues, ultimately accelerating organ dysfunction. However, the molecular mechanisms of pyroptosis in the multisystem damage induced by OSA remain unclear. Therefore, this review focuses on four major systems that have received concentrated attention in existing research in order to explore the role of pyroptosis in promoting renal diseases, cardiovascular diseases, neurocognitive diseases, and skin diseases in OSA patients. Furthermore, we provide a comprehensive overview of methods for inhibiting pyroptosis at different molecular levels, with the goal of identifying viable targets and therapeutic strategies for addressing OSA-related complications.https://www.mdpi.com/2218-273X/14/11/1349obstructive sleep apneapyroptosischronic intermittent hypoxiasleep deprivationNLRP3 inflammasome |
| spellingShingle | Jingwen Han Lisong Ye Yan Wang Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea Biomolecules obstructive sleep apnea pyroptosis chronic intermittent hypoxia sleep deprivation NLRP3 inflammasome |
| title | Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea |
| title_full | Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea |
| title_fullStr | Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea |
| title_full_unstemmed | Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea |
| title_short | Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea |
| title_sort | pyroptosis an accomplice in the induction of multisystem complications triggered by obstructive sleep apnea |
| topic | obstructive sleep apnea pyroptosis chronic intermittent hypoxia sleep deprivation NLRP3 inflammasome |
| url | https://www.mdpi.com/2218-273X/14/11/1349 |
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