Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow
Purpose. To compare a semiopen breathing circuit with a non-rebreathing (Hudson mask) for MRI experiments involving gas delivery. Methods and Materials. Cerebral blood flow (CBF) was measured by quantitative phase contrast angiography of the internal carotid and basilar arteries in 18 volunteers (20...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Radiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/694803 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467874080456704 |
|---|---|
| author | John R. Cain Laura M. Parkes Peter Eadsforth Susan C. Beards Alan Jackson |
| author_facet | John R. Cain Laura M. Parkes Peter Eadsforth Susan C. Beards Alan Jackson |
| author_sort | John R. Cain |
| collection | DOAJ |
| description | Purpose. To compare a semiopen breathing circuit with a non-rebreathing (Hudson mask) for MRI experiments involving gas delivery. Methods and Materials. Cerebral blood flow (CBF) was measured by quantitative phase contrast angiography of the internal carotid and basilar arteries in 18 volunteers (20–31 years). In 8 subjects, gases were delivered via a standard non-rebreathing (Hudson mask). In 10 subjects, gases were delivered using a modified “Mapleson A” semiopen anesthetic gas circuit and mouthpiece. All subjects were given 100% O2, medical air, and carbogen gas (95% O2 and 5% CO2) delivered at 15 L/min in a random order. Results. The Hudson mask group showed significant increases in CBF in response to increased FiCO2 compared to air (+9.8%). A small nonsignificant reduction in CBF (−2.4%) was seen in response to increased inspired concentrations of oxygen (FiO2). The Mapleson A group showed significantly larger changes in CBF in response to both increased inspired concentrations of carbon dioxide (FiCO2) (+32.2%, P<0.05) and FiO2 (−14.6%, P<0.01). Conclusions. The use of an anaesthetic gas delivery circuit avoids entrainment of room air and rebreathing effects that may otherwise adversely affect the experimental results. |
| format | Article |
| id | doaj-art-e12fe823a55f4e70a687b76845a9de09 |
| institution | Kabale University |
| issn | 2090-1941 2090-195X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Radiology Research and Practice |
| spelling | doaj-art-e12fe823a55f4e70a687b76845a9de092025-08-20T03:26:00ZengWileyRadiology Research and Practice2090-19412090-195X2013-01-01201310.1155/2013/694803694803Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood FlowJohn R. Cain0Laura M. Parkes1Peter Eadsforth2Susan C. Beards3Alan Jackson4Wolfson Molecular Imaging Centre, Cancer and Enabling Sciences, University of Manchester, 23 Palatine Road, Withington, Manchester M20 3LJ, UKWolfson Molecular Imaging Centre, Cancer and Enabling Sciences, University of Manchester, 23 Palatine Road, Withington, Manchester M20 3LJ, UKDepartment of Anaesthetics, Salford Royal Hospital, Stott Lane, Salford, Greater Manchester M6 8HD, UKAcute Intensive Care Unit, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, UKWolfson Molecular Imaging Centre, Cancer and Enabling Sciences, University of Manchester, 23 Palatine Road, Withington, Manchester M20 3LJ, UKPurpose. To compare a semiopen breathing circuit with a non-rebreathing (Hudson mask) for MRI experiments involving gas delivery. Methods and Materials. Cerebral blood flow (CBF) was measured by quantitative phase contrast angiography of the internal carotid and basilar arteries in 18 volunteers (20–31 years). In 8 subjects, gases were delivered via a standard non-rebreathing (Hudson mask). In 10 subjects, gases were delivered using a modified “Mapleson A” semiopen anesthetic gas circuit and mouthpiece. All subjects were given 100% O2, medical air, and carbogen gas (95% O2 and 5% CO2) delivered at 15 L/min in a random order. Results. The Hudson mask group showed significant increases in CBF in response to increased FiCO2 compared to air (+9.8%). A small nonsignificant reduction in CBF (−2.4%) was seen in response to increased inspired concentrations of oxygen (FiO2). The Mapleson A group showed significantly larger changes in CBF in response to both increased inspired concentrations of carbon dioxide (FiCO2) (+32.2%, P<0.05) and FiO2 (−14.6%, P<0.01). Conclusions. The use of an anaesthetic gas delivery circuit avoids entrainment of room air and rebreathing effects that may otherwise adversely affect the experimental results.http://dx.doi.org/10.1155/2013/694803 |
| spellingShingle | John R. Cain Laura M. Parkes Peter Eadsforth Susan C. Beards Alan Jackson Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow Radiology Research and Practice |
| title | Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow |
| title_full | Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow |
| title_fullStr | Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow |
| title_full_unstemmed | Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow |
| title_short | Impact of Gas Delivery Systems on Imaging Studies of Human Cerebral Blood Flow |
| title_sort | impact of gas delivery systems on imaging studies of human cerebral blood flow |
| url | http://dx.doi.org/10.1155/2013/694803 |
| work_keys_str_mv | AT johnrcain impactofgasdeliverysystemsonimagingstudiesofhumancerebralbloodflow AT lauramparkes impactofgasdeliverysystemsonimagingstudiesofhumancerebralbloodflow AT petereadsforth impactofgasdeliverysystemsonimagingstudiesofhumancerebralbloodflow AT susancbeards impactofgasdeliverysystemsonimagingstudiesofhumancerebralbloodflow AT alanjackson impactofgasdeliverysystemsonimagingstudiesofhumancerebralbloodflow |