Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

Abstract Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide association studies. Recognizing that linkage...

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Bibliographic Details
Main Authors: Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Research Notes
Subjects:
Methylation scores
Schizophrenia
Methylome-wide association studies
Summary statistics
LDpred2
Polygenic risk score
Online Access:https://doi.org/10.1186/s13104-025-07222-2
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