Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes
One of the most effective methods for continuous blood glucose monitoring is to continuously measure glucose in the interstitial fluid (ISF). However, multiple physiological factors can modulate glucose concentrations and affect the lag phase between blood and ISF glucose changes. This study aims to...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4596316 |
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| _version_ | 1832553578154164224 |
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| author | Ting Shi Dachao Li Guoqing Li Yiming Zhang Kexin Xu Luo Lu |
| author_facet | Ting Shi Dachao Li Guoqing Li Yiming Zhang Kexin Xu Luo Lu |
| author_sort | Ting Shi |
| collection | DOAJ |
| description | One of the most effective methods for continuous blood glucose monitoring is to continuously measure glucose in the interstitial fluid (ISF). However, multiple physiological factors can modulate glucose concentrations and affect the lag phase between blood and ISF glucose changes. This study aims to develop a compensatory tool for measuring the delay in ISF glucose variations in reference to blood glucose changes. A theoretical model was developed based on biophysics and physiology of glucose transport in the microcirculation system. Blood and interstitial fluid glucose changes were measured in mice and rats by fluorescent and isotope methods, respectively. Computer simulation mimicked curves were fitted with data resulting from fluorescent measurements of mice and isotope measurements of rats, indicating that there were lag times for ISF glucose changes. It also showed that there was a required diffusion distance for glucose to travel from center of capillaries to interstitial space in both mouse and rat models. We conclude that it is feasible with the developed model to continuously monitor dynamic changes of blood glucose concentration through measuring glucose changes in ISF with high accuracy, which requires correct parameters for determining and compensating for the delay time of glucose changes in ISF. |
| format | Article |
| id | doaj-art-e12c1c5e924742de99af6284804470ab |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e12c1c5e924742de99af6284804470ab2025-02-03T05:53:48ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/45963164596316Modeling and Measurement of Correlation between Blood and Interstitial Glucose ChangesTing Shi0Dachao Li1Guoqing Li2Yiming Zhang3Kexin Xu4Luo Lu5College of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, ChinaState Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, ChinaState Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, ChinaCollege of Electronic Information and Control Engineering, Beijing University of Technology, Beijing 100124, ChinaState Key Laboratory of Precision Measuring Technology and Instruments, Tianjin University, Tianjin 300072, ChinaDepartment of Medicine, University of California School of Medicine, Torrance, CA 90502, USAOne of the most effective methods for continuous blood glucose monitoring is to continuously measure glucose in the interstitial fluid (ISF). However, multiple physiological factors can modulate glucose concentrations and affect the lag phase between blood and ISF glucose changes. This study aims to develop a compensatory tool for measuring the delay in ISF glucose variations in reference to blood glucose changes. A theoretical model was developed based on biophysics and physiology of glucose transport in the microcirculation system. Blood and interstitial fluid glucose changes were measured in mice and rats by fluorescent and isotope methods, respectively. Computer simulation mimicked curves were fitted with data resulting from fluorescent measurements of mice and isotope measurements of rats, indicating that there were lag times for ISF glucose changes. It also showed that there was a required diffusion distance for glucose to travel from center of capillaries to interstitial space in both mouse and rat models. We conclude that it is feasible with the developed model to continuously monitor dynamic changes of blood glucose concentration through measuring glucose changes in ISF with high accuracy, which requires correct parameters for determining and compensating for the delay time of glucose changes in ISF.http://dx.doi.org/10.1155/2016/4596316 |
| spellingShingle | Ting Shi Dachao Li Guoqing Li Yiming Zhang Kexin Xu Luo Lu Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes Journal of Diabetes Research |
| title | Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes |
| title_full | Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes |
| title_fullStr | Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes |
| title_full_unstemmed | Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes |
| title_short | Modeling and Measurement of Correlation between Blood and Interstitial Glucose Changes |
| title_sort | modeling and measurement of correlation between blood and interstitial glucose changes |
| url | http://dx.doi.org/10.1155/2016/4596316 |
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