Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling
Headspace solid-phase microextraction (HSSPME) of volatile organic compounds (VOCs) from aqueous samples under vacuum conditions (Vac-HSSPME) allows increasing extraction rates and decreasing detection limits compared to HSSPME under atmospheric pressure. The positive effect of the vacuum on HSSPME...
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Elsevier
2024-11-01
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| author | Bulat Kenessov Aset Muratuly |
| author_facet | Bulat Kenessov Aset Muratuly |
| author_sort | Bulat Kenessov |
| collection | DOAJ |
| description | Headspace solid-phase microextraction (HSSPME) of volatile organic compounds (VOCs) from aqueous samples under vacuum conditions (Vac-HSSPME) allows increasing extraction rates and decreasing detection limits compared to HSSPME under atmospheric pressure. The positive effect of the vacuum on HSSPME of an analyte can be quickly estimated using its Henry's law constant (HLC). According to the two-layer model of evaporation, substantial positive effect of the vacuum can be expected for analytes with HLC lower than 1.6·10−4 atm m3 mol−1 (0.0065 at 25 °C), but the model does not consider possible effects of other important extraction parameters. This research was aimed at the evaluation of the possible effect of vacuum on the equilibration time and extracted amounts of analytes with various HLC and fiber coating-headspace distribution constants (Kfh) using the computational model recently developed in COMSOL Multiphysics® software. It has been proven that HSSPME under vacuum provides faster equilibration of VOCs with all studied Kfh and HLC. The largest vacuum effect on the extracted analyte amount was 3.9–4.0 times at logKfh = 6 and HLC = 10−6–10−3. The substantial (≥1.5 times) vacuum impact should not be expected for analytes with logKfh < 5 for 15-min extraction and logKfh < 5.5 for 30-min extraction. The vacuum impact should be more pronounced when using fiber coatings with a stronger affinity to analytes. The obtained results will be useful for the development of new methods based on Vac-HSSPME and evaluation whether HSSPME is reasonable to conduct under vacuum conditions for faster equilibration and/or lower detection limits. |
| format | Article |
| id | doaj-art-e122d6084b4f42bbbbf67921dbfd28ef |
| institution | DOAJ |
| issn | 2772-3917 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
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| series | Journal of Chromatography Open |
| spelling | doaj-art-e122d6084b4f42bbbbf67921dbfd28ef2025-08-20T02:39:18ZengElsevierJournal of Chromatography Open2772-39172024-11-01610014810.1016/j.jcoa.2024.100148Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modelingBulat Kenessov0Aset Muratuly1Correspondence author at: 050012 Almaty, 96a Tole bi Street, room 403, Kazakhstan.; Center of Physical Chemical Methods of Research and Analysis, Al-Farabi Kazakh National University, Almaty, KazakhstanCenter of Physical Chemical Methods of Research and Analysis, Al-Farabi Kazakh National University, Almaty, KazakhstanHeadspace solid-phase microextraction (HSSPME) of volatile organic compounds (VOCs) from aqueous samples under vacuum conditions (Vac-HSSPME) allows increasing extraction rates and decreasing detection limits compared to HSSPME under atmospheric pressure. The positive effect of the vacuum on HSSPME of an analyte can be quickly estimated using its Henry's law constant (HLC). According to the two-layer model of evaporation, substantial positive effect of the vacuum can be expected for analytes with HLC lower than 1.6·10−4 atm m3 mol−1 (0.0065 at 25 °C), but the model does not consider possible effects of other important extraction parameters. This research was aimed at the evaluation of the possible effect of vacuum on the equilibration time and extracted amounts of analytes with various HLC and fiber coating-headspace distribution constants (Kfh) using the computational model recently developed in COMSOL Multiphysics® software. It has been proven that HSSPME under vacuum provides faster equilibration of VOCs with all studied Kfh and HLC. The largest vacuum effect on the extracted analyte amount was 3.9–4.0 times at logKfh = 6 and HLC = 10−6–10−3. The substantial (≥1.5 times) vacuum impact should not be expected for analytes with logKfh < 5 for 15-min extraction and logKfh < 5.5 for 30-min extraction. The vacuum impact should be more pronounced when using fiber coatings with a stronger affinity to analytes. The obtained results will be useful for the development of new methods based on Vac-HSSPME and evaluation whether HSSPME is reasonable to conduct under vacuum conditions for faster equilibration and/or lower detection limits.http://www.sciencedirect.com/science/article/pii/S2772391724000355Solid-phase microextractionNumerical modelingCOMSOLWater analysisEffect of vacuumDistribution constant |
| spellingShingle | Bulat Kenessov Aset Muratuly Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling Journal of Chromatography Open Solid-phase microextraction Numerical modeling COMSOL Water analysis Effect of vacuum Distribution constant |
| title | Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| title_full | Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| title_fullStr | Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| title_full_unstemmed | Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| title_short | Evaluation of the vacuum effect on headspace solid-phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| title_sort | evaluation of the vacuum effect on headspace solid phase microextraction of volatile organic compounds from aqueous samples using finite element analysis modeling |
| topic | Solid-phase microextraction Numerical modeling COMSOL Water analysis Effect of vacuum Distribution constant |
| url | http://www.sciencedirect.com/science/article/pii/S2772391724000355 |
| work_keys_str_mv | AT bulatkenessov evaluationofthevacuumeffectonheadspacesolidphasemicroextractionofvolatileorganiccompoundsfromaqueoussamplesusingfiniteelementanalysismodeling AT asetmuratuly evaluationofthevacuumeffectonheadspacesolidphasemicroextractionofvolatileorganiccompoundsfromaqueoussamplesusingfiniteelementanalysismodeling |