Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank
Background Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression. Aims To assess the associati...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472424008457/type/journal_article |
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| _version_ | 1832576306948079616 |
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| author | Jaegyun Jung Sangyeon Lee Jeong Ho Lee Doheon Lee |
| author_facet | Jaegyun Jung Sangyeon Lee Jeong Ho Lee Doheon Lee |
| author_sort | Jaegyun Jung |
| collection | DOAJ |
| description | Background
Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression.
Aims
To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes.
Method
We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour.
Results
A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08–0.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour.
Conclusions
A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients.
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| format | Article |
| id | doaj-art-e0fc2e4cac3340549865461ec50d835a |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-e0fc2e4cac3340549865461ec50d835a2025-01-31T08:17:58ZengCambridge University PressBJPsych Open2056-47242025-01-011110.1192/bjo.2024.845Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobankJaegyun Jung0https://orcid.org/0000-0002-3222-2965Sangyeon Lee1Jeong Ho Lee2Doheon Lee3Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaBackground Physical activities are widely implemented for non-pharmacological intervention to alleviate depressive symptoms. However, there is little evidence supporting their genotype-specific effectiveness in reducing the risk of self-harm in patients with depression. Aims To assess the associations between physical activity and self-harm behaviour and determine the recommended level of physical activity across the genotypes. Method We developed the bidirectional analytical model to investigate the genotype-specific effectiveness on UK Biobank. After the genetic stratification of the depression phenotype cohort using hierarchical clustering, multivariable logistic regression models and Cox proportional hazards models were built to investigate the associations between physical activity and the risk of self-harm behaviour. Results A total of 28 923 subjects with depression phenotypes were included in the study. In retrospective cohort analysis, the moderate and highly active groups were at lower risk of self-harm behaviour. In the followed prospective cohort analysis, light-intensity physical activity was associated with a lower risk of hospitalisations due to self-harm behaviour in one genetic cluster (adjusted hazard ratio, 0.28 [95% CI, 0.08–0.96]), which was distinguished by three genetic variants: rs1432639, rs4543289 and rs11209948. Compliance with the guideline-level moderate-to-vigorous physical activities was not significantly related to the risk of self-harm behaviour. Conclusions A genotype-specific dose of light-intensity physical activity reduces the risk of self-harm by around a fourth in depressive patients. https://www.cambridge.org/core/product/identifier/S2056472424008457/type/journal_articleDepressive disordersself-harmbig datagenetic epidemiologyprecision medicine |
| spellingShingle | Jaegyun Jung Sangyeon Lee Jeong Ho Lee Doheon Lee Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank BJPsych Open Depressive disorders self-harm big data genetic epidemiology precision medicine |
| title | Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank |
| title_full | Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank |
| title_fullStr | Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank |
| title_full_unstemmed | Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank |
| title_short | Associations between physical activities and self-harm behaviour in depression across the genotype: findings from the UK biobank |
| title_sort | associations between physical activities and self harm behaviour in depression across the genotype findings from the uk biobank |
| topic | Depressive disorders self-harm big data genetic epidemiology precision medicine |
| url | https://www.cambridge.org/core/product/identifier/S2056472424008457/type/journal_article |
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