Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

Abstract Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there are no effective oral therapeutics for RSV infection. Obeldesivir (ODV) is an orally bioavailable prodrug of the nucleoside analog...

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Main Authors: Jared Pitts, J. Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Vincent Cutillas, Varsha Nair, Nicholas C. Riola, Arya Vijjapurapu, Meghan S. Vermillion, Stacey Eng, Christopher Richards, Dong Han, Jason K. Perry, Subhra Chaudhuri, Szu-Wen Liu, Clarissa Martinez, Nadine Peinovich, Kai-Hui Sun, Arthur Cai, Ross Martin, Jasmine Moshiri, Charlotte Hedskog, Darius Babusis, Dustin S. Siegel, Rao Kalla, Vasanthi Avadhanula, Pedro A. Piedra, Kim Stobbelaar, Peter L. Delputte, Caleb Marceau, Roberto Mateo, Evguenia Maiorova, Hongmei Mo, Raju Subramanian, Richard L. Mackman, Tomas Cihlar, Simon P. Fletcher, John P. Bilello
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61595-3
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