Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases
Protein kinases (PKs) are an important and very popular family of enzymes that play a vital role in regulating cellular processes via the phosphorylation of targets. Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disor...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Kinases and Phosphatases |
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| Online Access: | https://www.mdpi.com/2813-3757/2/4/23 |
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| author | Lorena Martínez-Alcantar Laura Hernández-Padilla Alma Laura Díaz-Pérez Lizbeth Guadalupe Villalón-Magallán Mayra Xóchitl Durán-Maldonado César Díaz-Pérez Marlene E. Campos-Morales Citlali Figueroa-Guzmán Jesús Campos-García |
| author_facet | Lorena Martínez-Alcantar Laura Hernández-Padilla Alma Laura Díaz-Pérez Lizbeth Guadalupe Villalón-Magallán Mayra Xóchitl Durán-Maldonado César Díaz-Pérez Marlene E. Campos-Morales Citlali Figueroa-Guzmán Jesús Campos-García |
| author_sort | Lorena Martínez-Alcantar |
| collection | DOAJ |
| description | Protein kinases (PKs) are an important and very popular family of enzymes that play a vital role in regulating cellular processes via the phosphorylation of targets. Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. Cyclic ultra-short peptides are amazing structures with unique properties. The cyclicity of cyclic peptides (CPs) can mimic the interactions between PKs and natural substrates, influencing the enzyme activity essential in health and disease physiology. Our review summarized that interference in the signal transduction mechanism of the PKs by CPs implies the inhibition of substrate phosphorylation at the level of the active site, similar to anti-neoplastic drugs. The remarkable capacity of CPs to interact with targets positions them as promising candidates for developing protein kinase inhibitors in treating diseases. This review offers new insights for CPs in molecular mechanisms, cytotoxicity, target selectivity, and the possibility of designing more effective and safe therapeutic agents. |
| format | Article |
| id | doaj-art-e0ce303935924808a8a03d6f12bd6a99 |
| institution | Kabale University |
| issn | 2813-3757 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Kinases and Phosphatases |
| spelling | doaj-art-e0ce303935924808a8a03d6f12bd6a992025-01-24T13:37:29ZengMDPI AGKinases and Phosphatases2813-37572024-12-012434637810.3390/kinasesphosphatases2040023Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human DiseasesLorena Martínez-Alcantar0Laura Hernández-Padilla1Alma Laura Díaz-Pérez2Lizbeth Guadalupe Villalón-Magallán3Mayra Xóchitl Durán-Maldonado4César Díaz-Pérez5Marlene E. Campos-Morales6Citlali Figueroa-Guzmán7Jesús Campos-García8Laboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoComisión Intersecretarial de Bioseguridad de los Organismos Genéticamente Modificados (CIBIOGEM), Consejo Nacional de Humanidades Ciencias y Tecnologías (CONAHCYT), Mexico City 03940, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoDepartamento de Ingeniería Agroindustrial, Universiad de Guanajuato, Guanajuato 38140, Gto, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoLaboratorio de Biotecnología Microbiana, Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mich, MexicoProtein kinases (PKs) are an important and very popular family of enzymes that play a vital role in regulating cellular processes via the phosphorylation of targets. Nevertheless, modifications in the expression due to mutations or their dysregulation can lead to diseases, including autoimmune disorders, cardiovascular problems, diabetes, neurological diseases, and cancers. Cyclic ultra-short peptides are amazing structures with unique properties. The cyclicity of cyclic peptides (CPs) can mimic the interactions between PKs and natural substrates, influencing the enzyme activity essential in health and disease physiology. Our review summarized that interference in the signal transduction mechanism of the PKs by CPs implies the inhibition of substrate phosphorylation at the level of the active site, similar to anti-neoplastic drugs. The remarkable capacity of CPs to interact with targets positions them as promising candidates for developing protein kinase inhibitors in treating diseases. This review offers new insights for CPs in molecular mechanisms, cytotoxicity, target selectivity, and the possibility of designing more effective and safe therapeutic agents.https://www.mdpi.com/2813-3757/2/4/23protein kinasesprotein kinase inhibitorscyclic peptidescyclodipeptidesanti-neoplastic drugstherapeutic targets |
| spellingShingle | Lorena Martínez-Alcantar Laura Hernández-Padilla Alma Laura Díaz-Pérez Lizbeth Guadalupe Villalón-Magallán Mayra Xóchitl Durán-Maldonado César Díaz-Pérez Marlene E. Campos-Morales Citlali Figueroa-Guzmán Jesús Campos-García Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases Kinases and Phosphatases protein kinases protein kinase inhibitors cyclic peptides cyclodipeptides anti-neoplastic drugs therapeutic targets |
| title | Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases |
| title_full | Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases |
| title_fullStr | Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases |
| title_full_unstemmed | Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases |
| title_short | Cyclic Peptides as Protein Kinase Modulators and Their Involvement in the Treatment of Diverse Human Diseases |
| title_sort | cyclic peptides as protein kinase modulators and their involvement in the treatment of diverse human diseases |
| topic | protein kinases protein kinase inhibitors cyclic peptides cyclodipeptides anti-neoplastic drugs therapeutic targets |
| url | https://www.mdpi.com/2813-3757/2/4/23 |
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