Molecular Network Associated with MITF in Skin Melanoma Development and Progression
Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first t...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/730170 |
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| author | Ichiro Yajima Mayuko Y. Kumasaka Nguyen Dinh Thang Yuji Goto Kozue Takeda Machiko Iida Nobutaka Ohgami Haruka Tamura Osamu Yamanoshita Yoshiyuki Kawamoto Keiko Furukawa Masashi Kato |
| author_facet | Ichiro Yajima Mayuko Y. Kumasaka Nguyen Dinh Thang Yuji Goto Kozue Takeda Machiko Iida Nobutaka Ohgami Haruka Tamura Osamu Yamanoshita Yoshiyuki Kawamoto Keiko Furukawa Masashi Kato |
| author_sort | Ichiro Yajima |
| collection | DOAJ |
| description | Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression. Microphthalmia-associated transcription factor (MITF) is a master regulator gene of melanocyte development and differentiation and is also associated with melanoma development and progression. To find better approaches to molecular-based therapies for patients, understanding MITF function in skin melanoma development and progression is important. Here, we review the molecular networks associated with MITF in skin melanoma development and progression. |
| format | Article |
| id | doaj-art-e0cd2a808bdf47e89799984a9a1aa535 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-e0cd2a808bdf47e89799984a9a1aa5352025-02-03T01:27:13ZengWileyJournal of Skin Cancer2090-29052090-29132011-01-01201110.1155/2011/730170730170Molecular Network Associated with MITF in Skin Melanoma Development and ProgressionIchiro Yajima0Mayuko Y. Kumasaka1Nguyen Dinh Thang2Yuji Goto3Kozue Takeda4Machiko Iida5Nobutaka Ohgami6Haruka Tamura7Osamu Yamanoshita8Yoshiyuki Kawamoto9Keiko Furukawa10Masashi Kato11Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Immunology, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanHealth Science Hills, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanUnit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi 487-8501, JapanVarious environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epigenetic alterations occur in skin melanocytes. These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression. Microphthalmia-associated transcription factor (MITF) is a master regulator gene of melanocyte development and differentiation and is also associated with melanoma development and progression. To find better approaches to molecular-based therapies for patients, understanding MITF function in skin melanoma development and progression is important. Here, we review the molecular networks associated with MITF in skin melanoma development and progression.http://dx.doi.org/10.1155/2011/730170 |
| spellingShingle | Ichiro Yajima Mayuko Y. Kumasaka Nguyen Dinh Thang Yuji Goto Kozue Takeda Machiko Iida Nobutaka Ohgami Haruka Tamura Osamu Yamanoshita Yoshiyuki Kawamoto Keiko Furukawa Masashi Kato Molecular Network Associated with MITF in Skin Melanoma Development and Progression Journal of Skin Cancer |
| title | Molecular Network Associated with MITF in Skin Melanoma Development and Progression |
| title_full | Molecular Network Associated with MITF in Skin Melanoma Development and Progression |
| title_fullStr | Molecular Network Associated with MITF in Skin Melanoma Development and Progression |
| title_full_unstemmed | Molecular Network Associated with MITF in Skin Melanoma Development and Progression |
| title_short | Molecular Network Associated with MITF in Skin Melanoma Development and Progression |
| title_sort | molecular network associated with mitf in skin melanoma development and progression |
| url | http://dx.doi.org/10.1155/2011/730170 |
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