Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?

Diabetes mellitus (DM), the most common metabolic disease, might affect different organs such as male reproductive system. Experiments have shown that n-3 fatty acids could improve male reproductive function. Present study was performed to examine the effects of omega3 on sperms and testicular param...

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Main Authors: Atefe Yaghoubi, Abbas Shahedi, Hakime Akbari, Seyed Noureddin Nematollahi-Mahani
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2017/6102985
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author Atefe Yaghoubi
Abbas Shahedi
Hakime Akbari
Seyed Noureddin Nematollahi-Mahani
author_facet Atefe Yaghoubi
Abbas Shahedi
Hakime Akbari
Seyed Noureddin Nematollahi-Mahani
author_sort Atefe Yaghoubi
collection DOAJ
description Diabetes mellitus (DM), the most common metabolic disease, might affect different organs such as male reproductive system. Experiments have shown that n-3 fatty acids could improve male reproductive function. Present study was performed to examine the effects of omega3 on sperms and testicular parameters in diabetic mice. Adult NMRI male mice were randomly divided into intact and diabetic groups (n=8). Streptozotocin-induced diabetic animals were divided into 4 groups of diabetic-saline (Dia-Sa), diabetic-insulin (Dia-Ins), diabetic-omega3 (Dia-omg3), and diabetic-insulin-omega3 (Dia-Ins-omg3). Following confirmation of diabetes, different treatments including 3 U/100 g insulin subcutaneously and 400 mg/kg omega3 orally were administered, where applicable according to the treatment groups. Thirty-five days later, the sperm number, motility, progression, and normal morphology were determined. Also, testes diameters and structure including germinal epithelium thickness, seminiferous tubule diameters, Leydig cell number, and testosterone level were assessed. Sperm number, viability, fast motility, testes volume, and serum testosterone level decreased insignificantly in the Dia-Sa group compared with the intact animals. Neither insulin replacement nor omega3 administration could significantly improve the outcome. We might conclude that short periods of diabetes could not significantly affect the male reproductive function. In addition, insulin replacement and/or omega-3 supplementation does not have any profound effects on male reproductive system.
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spelling doaj-art-e0cb2eeca3874fb4b9e443bef8d67ee82025-08-20T03:25:59ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322017-01-01201710.1155/2017/61029856102985Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?Atefe Yaghoubi0Abbas Shahedi1Hakime Akbari2Seyed Noureddin Nematollahi-Mahani3Department of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Anatomy, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Anatomy, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, IranPhysiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranDiabetes mellitus (DM), the most common metabolic disease, might affect different organs such as male reproductive system. Experiments have shown that n-3 fatty acids could improve male reproductive function. Present study was performed to examine the effects of omega3 on sperms and testicular parameters in diabetic mice. Adult NMRI male mice were randomly divided into intact and diabetic groups (n=8). Streptozotocin-induced diabetic animals were divided into 4 groups of diabetic-saline (Dia-Sa), diabetic-insulin (Dia-Ins), diabetic-omega3 (Dia-omg3), and diabetic-insulin-omega3 (Dia-Ins-omg3). Following confirmation of diabetes, different treatments including 3 U/100 g insulin subcutaneously and 400 mg/kg omega3 orally were administered, where applicable according to the treatment groups. Thirty-five days later, the sperm number, motility, progression, and normal morphology were determined. Also, testes diameters and structure including germinal epithelium thickness, seminiferous tubule diameters, Leydig cell number, and testosterone level were assessed. Sperm number, viability, fast motility, testes volume, and serum testosterone level decreased insignificantly in the Dia-Sa group compared with the intact animals. Neither insulin replacement nor omega3 administration could significantly improve the outcome. We might conclude that short periods of diabetes could not significantly affect the male reproductive function. In addition, insulin replacement and/or omega-3 supplementation does not have any profound effects on male reproductive system.http://dx.doi.org/10.1155/2017/6102985
spellingShingle Atefe Yaghoubi
Abbas Shahedi
Hakime Akbari
Seyed Noureddin Nematollahi-Mahani
Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
Journal of Nutrition and Metabolism
title Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
title_full Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
title_fullStr Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
title_full_unstemmed Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
title_short Do Insulin Replacement and Omega3 Protect the Male Reproductive Function of the Streptozotocin-Induced Diabetic Mice?
title_sort do insulin replacement and omega3 protect the male reproductive function of the streptozotocin induced diabetic mice
url http://dx.doi.org/10.1155/2017/6102985
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