Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review
The uveitis-glaucoma-hyphema (UGH) syndrome, initially described in 1978, presents as an iatrogenic complication associated with contact between intraocular implant and ocular tissue. This syndrome encompasses a spectrum of clinical manifestations, including intraocular inflammation, elevated intrao...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-08-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/8/20250822.pdf |
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| author | Jing-Ting Luo Zhao-Xun Feng Cong Wang |
| author_facet | Jing-Ting Luo Zhao-Xun Feng Cong Wang |
| author_sort | Jing-Ting Luo |
| collection | DOAJ |
| description | The uveitis-glaucoma-hyphema (UGH) syndrome, initially described in 1978, presents as an iatrogenic complication associated with contact between intraocular implant and ocular tissue. This syndrome encompasses a spectrum of clinical manifestations, including intraocular inflammation, elevated intraocular pressure, and recurrent hemorrhage. Advances in cataract surgery techniques reduced the incidence of early intraocular lens (IOL) dislocation while inversely increased rates of delayed dislocation. The primary etiology of UGH syndrome is IOL subluxation. Weakness of the ciliary zonules or unstable IOL fixation techniques may predispose the eye to iris-lens contact. Other contributing factors include Soemmering's ring formation, abnormal iris and ciliary body anatomy, positional changes, and improper positioning of glaucoma implants. Clinical examination and imaging modalities such as ultrasound biomicroscopy and anterior segment optical coherence tomography supports diagnosis of UGH. Treatment options range from observation and medical therapies to invasive procedures such as laser therapy, IOL repositioning, or replacement. Endoscopy provides direct visualization for identifying causes intraoperatively, aiding in tailored surgical approaches towards minimal intervention. In conclusion, UGH syndrome poses a complex clinical challenge, emphasizing the importance of understanding its etiology, accurate diagnosis, and personalized management strategies to mitigate its impact on visual function and ensure favorable outcomes. |
| format | Article |
| id | doaj-art-e0bbf300390a4e94a9c665aec2d7e761 |
| institution | DOAJ |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-e0bbf300390a4e94a9c665aec2d7e7612025-08-20T03:12:38ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-08-011881587159310.18240/ijo.2025.08.2220250822Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive reviewJing-Ting Luo0Zhao-Xun Feng1Cong Wang2Cong Wang. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. wxcc518@163.comDepartment of Ophthalmology, University of Ottawa, Ottawa, ON K1H 8L6, CanadaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaThe uveitis-glaucoma-hyphema (UGH) syndrome, initially described in 1978, presents as an iatrogenic complication associated with contact between intraocular implant and ocular tissue. This syndrome encompasses a spectrum of clinical manifestations, including intraocular inflammation, elevated intraocular pressure, and recurrent hemorrhage. Advances in cataract surgery techniques reduced the incidence of early intraocular lens (IOL) dislocation while inversely increased rates of delayed dislocation. The primary etiology of UGH syndrome is IOL subluxation. Weakness of the ciliary zonules or unstable IOL fixation techniques may predispose the eye to iris-lens contact. Other contributing factors include Soemmering's ring formation, abnormal iris and ciliary body anatomy, positional changes, and improper positioning of glaucoma implants. Clinical examination and imaging modalities such as ultrasound biomicroscopy and anterior segment optical coherence tomography supports diagnosis of UGH. Treatment options range from observation and medical therapies to invasive procedures such as laser therapy, IOL repositioning, or replacement. Endoscopy provides direct visualization for identifying causes intraoperatively, aiding in tailored surgical approaches towards minimal intervention. In conclusion, UGH syndrome poses a complex clinical challenge, emphasizing the importance of understanding its etiology, accurate diagnosis, and personalized management strategies to mitigate its impact on visual function and ensure favorable outcomes.http://ies.ijo.cn/en_publish/2025/8/20250822.pdfuveitis-glaucoma-hyphema syndromeetiologymanagement |
| spellingShingle | Jing-Ting Luo Zhao-Xun Feng Cong Wang Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review International Journal of Ophthalmology uveitis-glaucoma-hyphema syndrome etiology management |
| title | Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review |
| title_full | Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review |
| title_fullStr | Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review |
| title_full_unstemmed | Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review |
| title_short | Etiology and management of uveitis-glaucoma-hyphema syndrome: a comprehensive review |
| title_sort | etiology and management of uveitis glaucoma hyphema syndrome a comprehensive review |
| topic | uveitis-glaucoma-hyphema syndrome etiology management |
| url | http://ies.ijo.cn/en_publish/2025/8/20250822.pdf |
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