Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents
Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited. Objective: To investigate the association between neoni...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000442 |
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| author | Qian Su Jinzhu Luo You Zhou Miao Liu Shaohua Zeng Yin Li Jieying Gao |
| author_facet | Qian Su Jinzhu Luo You Zhou Miao Liu Shaohua Zeng Yin Li Jieying Gao |
| author_sort | Qian Su |
| collection | DOAJ |
| description | Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited. Objective: To investigate the association between neonicotinoid exposure and obesity among U.S. children and adolescents and to explore underlying mechanism mediated by serum sex steroid hormones in these associations. Methods: Data from the 2015–2016 National Health and Nutrition Examination Survey were used for the analysis. Generalized linear regression was used to investigate the association between detectable neonicotinoids and ten measures of obesity. The interaction effects of multiple neonicotinoids were determined by Chi-squared Automatic Interaction Detection method. Mediation analysis was used to assess potential mediators of sex steroid hormones, including testosterone (T), estradiol (E2), T/E2, sex hormone-binding globulin (SHBG), and free androgen index (FAI). Results: Clothianidin (β = −0.29, 95 % CI: −0.57, −0.01) and N-desmethyl-acetamiprid (β = −0.19, 95 % CI: −0.35, −0.03) were associated with reduced VFI z-score. After stratification, 5-hydroxy-imidacloprid was positively associated with the risk of general obesity in males (OR=2.24, 95 % CI: 1.20, 4.20) with a probability of 52.5 %. FAI mediated 15 % of the association between neonicotinoid exposure and reduced risk of obesity, and SHBG mediated 30 % of the association between neonicotinoid exposure and increased risk of obesity. Conclusion: Neonicotinoids showed associations with obesity, but the results were mixed and sex-specific. Sex steroid hormones may play a role in mediating the effects of neonicotinoids on obesity. |
| format | Article |
| id | doaj-art-e0acfcd6d0804e4498e2f014c0885335 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e0acfcd6d0804e4498e2f014c08853352025-01-23T05:26:11ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117708Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescentsQian Su0Jinzhu Luo1You Zhou2Miao Liu3Shaohua Zeng4Yin Li5Jieying Gao6School of Public Health, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health, Chongqing Medical University, Chongqing 400016, PR ChinaChongqing Yuzhong Center for Disease Control and Prevention, Chongqing 400010, PR ChinaChina Coal Technology & Engineering Group Chongqing Research Institute, Chongqing 400039, PR ChinaSchool of Public Health, Chongqing Medical University, Chongqing 400016, PR ChinaSchool of Public Health, Chongqing Medical University, Chongqing 400016, PR China; Correspondence to: No. 1, Yixueyuan Road, Yuzhong District, Chongqing 400016, PR China.Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. However, the evidence is limited. Objective: To investigate the association between neonicotinoid exposure and obesity among U.S. children and adolescents and to explore underlying mechanism mediated by serum sex steroid hormones in these associations. Methods: Data from the 2015–2016 National Health and Nutrition Examination Survey were used for the analysis. Generalized linear regression was used to investigate the association between detectable neonicotinoids and ten measures of obesity. The interaction effects of multiple neonicotinoids were determined by Chi-squared Automatic Interaction Detection method. Mediation analysis was used to assess potential mediators of sex steroid hormones, including testosterone (T), estradiol (E2), T/E2, sex hormone-binding globulin (SHBG), and free androgen index (FAI). Results: Clothianidin (β = −0.29, 95 % CI: −0.57, −0.01) and N-desmethyl-acetamiprid (β = −0.19, 95 % CI: −0.35, −0.03) were associated with reduced VFI z-score. After stratification, 5-hydroxy-imidacloprid was positively associated with the risk of general obesity in males (OR=2.24, 95 % CI: 1.20, 4.20) with a probability of 52.5 %. FAI mediated 15 % of the association between neonicotinoid exposure and reduced risk of obesity, and SHBG mediated 30 % of the association between neonicotinoid exposure and increased risk of obesity. Conclusion: Neonicotinoids showed associations with obesity, but the results were mixed and sex-specific. Sex steroid hormones may play a role in mediating the effects of neonicotinoids on obesity.http://www.sciencedirect.com/science/article/pii/S0147651325000442NeonicotinoidsObesityChildren and adolescentsSex steroid hormonesMediation analysis |
| spellingShingle | Qian Su Jinzhu Luo You Zhou Miao Liu Shaohua Zeng Yin Li Jieying Gao Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents Ecotoxicology and Environmental Safety Neonicotinoids Obesity Children and adolescents Sex steroid hormones Mediation analysis |
| title | Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| title_full | Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| title_fullStr | Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| title_full_unstemmed | Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| title_short | Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| title_sort | sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents |
| topic | Neonicotinoids Obesity Children and adolescents Sex steroid hormones Mediation analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000442 |
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