Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice

Serotonin release mediates analgesia via opioidergic system and withdrawal symptoms in chronic kratom extract-treated mice

Abstract Background Kratom alleviates pain by activating μu-opioid receptors (MOR), which trigger serotonin release to produce analgesia. Serotonin also interferes drug abuse effect. This study aimed to determine the role of serotonin in kratom-induced pain relief and withdrawal symptoms in mice. Me...

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Main Authors: Dwi Wahyu Indriani, Siti Irma Rahmawati, Asep Bayu, Peni Ahmadi, Anissa Nofita Sari, Zuraida Zuraida, Ni Luh Putu Indi Dharmayanti, Masteria Yunovilsa Putra
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Alkaloid kratom
Morphine
Analgesic
Withdrawal symptoms
Serotonin
Dopamine
Online Access:https://doi.org/10.1186/s12906-025-04947-2
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https://doi.org/10.1186/s12906-025-04947-2

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