Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score
Abstract Background We evaluated the association between serum levels of insulin‐like growth factor‐1 (IGF‐1), bioavailable testosterone, and surgical Gleason score (GS). Methods We analyzed 793 patients who underwent radical prostatectomy and 272 men with negative prostate biopsy. Serum levels of I...
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| Format: | Article |
| Language: | English |
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Wiley
2018-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1681 |
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| author | Myong Kim Jong Won Kim Jong Keun Kim Sang Mi Lee Cheryn Song In Gab Jeong Jun Hyuk Hong Choung‐Soo Kim Hanjong Ahn |
| author_facet | Myong Kim Jong Won Kim Jong Keun Kim Sang Mi Lee Cheryn Song In Gab Jeong Jun Hyuk Hong Choung‐Soo Kim Hanjong Ahn |
| author_sort | Myong Kim |
| collection | DOAJ |
| description | Abstract Background We evaluated the association between serum levels of insulin‐like growth factor‐1 (IGF‐1), bioavailable testosterone, and surgical Gleason score (GS). Methods We analyzed 793 patients who underwent radical prostatectomy and 272 men with negative prostate biopsy. Serum levels of IGF‐1 and testosterone were measured before surgery or biopsy. Results The mean IGF‐1 levels of prostate cancer patients and men with a negative biopsy were 143.8 and 118.9 ng/mL, respectively (P < 0.001). Men with high serum IGF‐1 were more likely to have prostate cancer (highest vs lowest quartile, odds ratio [OR] = 3.35; Ptrend < 0.001). However, among men with prostate cancer, the mean IGF‐1 levels of those with low (GS ≤ 6), intermediate (GS = 7), and high surgical GS (GS ≥8) were 151.7, 144.1, and 132.9 ng/mL, respectively (P < 0.001). Using quartile analysis, high serum IGF‐1 levels were shown to be associated with a low risk of high surgical GS (OR = 0.464; Ptrend = 0.006). Serum bioavailable testosterone concentration was positively correlated with serum IGF‐1 level (r = 0.157, P < 0.001). High bioavailable testosterone level was also associated with a low risk of high surgical GS in patients without diabetes mellitus (OR = 0.569; Ptrend = 0.040). Among men with biopsy GS ≤ 3 + 4 (n = 460), upgrading to high surgical GS was more frequent in patients with low IGF‐1 level (≤116.0 ng/mL; 9.9%) or low bioavailable testosterone level (≤0.85 ng/mL; 9.3%) than in patients with normal IGF‐1 and bioavailable testosterone levels (2.6%; P = 0.004). Conclusions Serum levels of IGF‐1 and bioavailable testosterone show inverse associations with high surgical GS. This suggests that high‐grade prostate cancer develops independently of these two substances. |
| format | Article |
| id | doaj-art-e0a89f2d9cd64b8e84363d4a7fdb9d08 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-e0a89f2d9cd64b8e84363d4a7fdb9d082025-08-20T02:40:11ZengWileyCancer Medicine2045-76342018-08-01784170418010.1002/cam4.1681Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason scoreMyong Kim0Jong Won Kim1Jong Keun Kim2Sang Mi Lee3Cheryn Song4In Gab Jeong5Jun Hyuk Hong6Choung‐Soo Kim7Hanjong Ahn8Department of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Korea Cancer Center Hospital Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaDepartment of Urology Asan Medical Center University of Ulsan College of Medicine Seoul KoreaAbstract Background We evaluated the association between serum levels of insulin‐like growth factor‐1 (IGF‐1), bioavailable testosterone, and surgical Gleason score (GS). Methods We analyzed 793 patients who underwent radical prostatectomy and 272 men with negative prostate biopsy. Serum levels of IGF‐1 and testosterone were measured before surgery or biopsy. Results The mean IGF‐1 levels of prostate cancer patients and men with a negative biopsy were 143.8 and 118.9 ng/mL, respectively (P < 0.001). Men with high serum IGF‐1 were more likely to have prostate cancer (highest vs lowest quartile, odds ratio [OR] = 3.35; Ptrend < 0.001). However, among men with prostate cancer, the mean IGF‐1 levels of those with low (GS ≤ 6), intermediate (GS = 7), and high surgical GS (GS ≥8) were 151.7, 144.1, and 132.9 ng/mL, respectively (P < 0.001). Using quartile analysis, high serum IGF‐1 levels were shown to be associated with a low risk of high surgical GS (OR = 0.464; Ptrend = 0.006). Serum bioavailable testosterone concentration was positively correlated with serum IGF‐1 level (r = 0.157, P < 0.001). High bioavailable testosterone level was also associated with a low risk of high surgical GS in patients without diabetes mellitus (OR = 0.569; Ptrend = 0.040). Among men with biopsy GS ≤ 3 + 4 (n = 460), upgrading to high surgical GS was more frequent in patients with low IGF‐1 level (≤116.0 ng/mL; 9.9%) or low bioavailable testosterone level (≤0.85 ng/mL; 9.3%) than in patients with normal IGF‐1 and bioavailable testosterone levels (2.6%; P = 0.004). Conclusions Serum levels of IGF‐1 and bioavailable testosterone show inverse associations with high surgical GS. This suggests that high‐grade prostate cancer develops independently of these two substances.https://doi.org/10.1002/cam4.1681bioavailable testosteroneGleason scoreinsulin‐like growth factor‐1pathologyprostate cancer |
| spellingShingle | Myong Kim Jong Won Kim Jong Keun Kim Sang Mi Lee Cheryn Song In Gab Jeong Jun Hyuk Hong Choung‐Soo Kim Hanjong Ahn Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score Cancer Medicine bioavailable testosterone Gleason score insulin‐like growth factor‐1 pathology prostate cancer |
| title | Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score |
| title_full | Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score |
| title_fullStr | Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score |
| title_full_unstemmed | Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score |
| title_short | Association between serum levels of insulin‐like growth factor‐1, bioavailable testosterone, and pathologic Gleason score |
| title_sort | association between serum levels of insulin like growth factor 1 bioavailable testosterone and pathologic gleason score |
| topic | bioavailable testosterone Gleason score insulin‐like growth factor‐1 pathology prostate cancer |
| url | https://doi.org/10.1002/cam4.1681 |
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