Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases
Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients di...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/986527 |
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| author | Qing Ye Xiao-Jun Xu Wen-Xia Shao Yan-Xiang Pan Xue-Jun Chen |
| author_facet | Qing Ye Xiao-Jun Xu Wen-Xia Shao Yan-Xiang Pan Xue-Jun Chen |
| author_sort | Qing Ye |
| collection | DOAJ |
| description | Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients diagnosed with pneumonia to investigate the patient immune status by determining the correlation between MP infection, immunoglobulin E (IgE) levels, and a spectrum of associated serum cytokines. Serum IgE, IL-4, IL-6, and IL-10 levels for MPP patients in the acute phase were obviously higher than those in the recovery phase (P<0.01). MPP patients with allergic conditions had increased serum IgE levels and increased IL-4/INF-γ ratio, and IgE and Eosinophil Cationic Protein were further elevated in patients who eventually developed secondary asthma changes. Patients with severe pneumonia and high clinical pulmonary infection scores presented higher levels of IL-4 and IL-5 in serum than those with low scores (P<0.01). The proportion of CD4+ and CD8+ T cells that secreted IL-4 was significantly increased in MPP patients with elevated IgE. Our data demonstrate a significant correlation between MP infection and IgE levels, which is associated with a Th1/Th2 cytokine imbalance. |
| format | Article |
| id | doaj-art-e0a6b1fd317b4c58a6521cfceb555c64 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e0a6b1fd317b4c58a6521cfceb555c642025-02-03T01:24:35ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/986527986527Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic DiseasesQing Ye0Xiao-Jun Xu1Wen-Xia Shao2Yan-Xiang Pan3Xue-Jun Chen4Clinical Laboratory, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaThe Department of Hematology/Oncology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310003, ChinaClinical Laboratory, Hangzhou First People’s Hospital, Hangzhou 310003, ChinaClinical Laboratory, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaClinical Laboratory, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaMycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients diagnosed with pneumonia to investigate the patient immune status by determining the correlation between MP infection, immunoglobulin E (IgE) levels, and a spectrum of associated serum cytokines. Serum IgE, IL-4, IL-6, and IL-10 levels for MPP patients in the acute phase were obviously higher than those in the recovery phase (P<0.01). MPP patients with allergic conditions had increased serum IgE levels and increased IL-4/INF-γ ratio, and IgE and Eosinophil Cationic Protein were further elevated in patients who eventually developed secondary asthma changes. Patients with severe pneumonia and high clinical pulmonary infection scores presented higher levels of IL-4 and IL-5 in serum than those with low scores (P<0.01). The proportion of CD4+ and CD8+ T cells that secreted IL-4 was significantly increased in MPP patients with elevated IgE. Our data demonstrate a significant correlation between MP infection and IgE levels, which is associated with a Th1/Th2 cytokine imbalance.http://dx.doi.org/10.1155/2014/986527 |
| spellingShingle | Qing Ye Xiao-Jun Xu Wen-Xia Shao Yan-Xiang Pan Xue-Jun Chen Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases The Scientific World Journal |
| title | Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases |
| title_full | Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases |
| title_fullStr | Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases |
| title_full_unstemmed | Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases |
| title_short | Mycoplasma pneumoniae Infection in Children Is a Risk Factor for Developing Allergic Diseases |
| title_sort | mycoplasma pneumoniae infection in children is a risk factor for developing allergic diseases |
| url | http://dx.doi.org/10.1155/2014/986527 |
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