Angiogenic Factors and Renal Disease in Pregnancy
Background. Preeclampsia is difficult to diagnose in patients with underlying renal disease and proteinuria. Prior studies show that there is an angiogenic factor imbalance with elevated levels of antiangiogenic proteins soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) and redu...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2011/281391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558693115232256 |
|---|---|
| author | Julie S. Rhee Brett C. Young Sarosh Rana |
| author_facet | Julie S. Rhee Brett C. Young Sarosh Rana |
| author_sort | Julie S. Rhee |
| collection | DOAJ |
| description | Background. Preeclampsia is difficult to diagnose in patients with underlying renal disease and proteinuria. Prior studies show that there is an angiogenic factor imbalance with elevated levels of antiangiogenic proteins soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) and reduced levels of the proangiogenic protein, placental growth factor (PlGF) in women with preeclampsia. These angiogenic biomarkers may be useful in distinguishing preeclampsia from other conditions of pregnancy, which may present with overlapping clinical characteristics. Cases. Case 1: A multiparous woman at 18 weeks gestation with nephrotic syndrome presented with hypertensive emergency and worsening renal insufficiency. She underwent induction of labor for severe preeclampsia. Her sFlt1 and sEng levels were at the 97 percentile while her PlGF level was undetectable (less than the 1st percentile). Case 2: A nulliparous woman with lupus nephritis at 22 weeks gestation presented with fetal demise and heart failure. Three weeks previously, the patient had developed thrombocytopenia and hypertensive urgency. She underwent dilation and evacuation. Her angiogenic profile was consistent with severe preeclampsia. Conclusion. Angiogenic factors may provide evidence to support a diagnosis of preeclampsia in patients with preexisting renal disease and proteinuria, conditions in which the classical definition of hypertension and proteinuria cannot be used. |
| format | Article |
| id | doaj-art-e0a269df66d343dbbe15a4df2c8e3552 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-e0a269df66d343dbbe15a4df2c8e35522025-02-03T01:31:49ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922011-01-01201110.1155/2011/281391281391Angiogenic Factors and Renal Disease in PregnancyJulie S. Rhee0Brett C. Young1Sarosh Rana2Department Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADepartment Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USADepartment Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USABackground. Preeclampsia is difficult to diagnose in patients with underlying renal disease and proteinuria. Prior studies show that there is an angiogenic factor imbalance with elevated levels of antiangiogenic proteins soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) and reduced levels of the proangiogenic protein, placental growth factor (PlGF) in women with preeclampsia. These angiogenic biomarkers may be useful in distinguishing preeclampsia from other conditions of pregnancy, which may present with overlapping clinical characteristics. Cases. Case 1: A multiparous woman at 18 weeks gestation with nephrotic syndrome presented with hypertensive emergency and worsening renal insufficiency. She underwent induction of labor for severe preeclampsia. Her sFlt1 and sEng levels were at the 97 percentile while her PlGF level was undetectable (less than the 1st percentile). Case 2: A nulliparous woman with lupus nephritis at 22 weeks gestation presented with fetal demise and heart failure. Three weeks previously, the patient had developed thrombocytopenia and hypertensive urgency. She underwent dilation and evacuation. Her angiogenic profile was consistent with severe preeclampsia. Conclusion. Angiogenic factors may provide evidence to support a diagnosis of preeclampsia in patients with preexisting renal disease and proteinuria, conditions in which the classical definition of hypertension and proteinuria cannot be used.http://dx.doi.org/10.1155/2011/281391 |
| spellingShingle | Julie S. Rhee Brett C. Young Sarosh Rana Angiogenic Factors and Renal Disease in Pregnancy Case Reports in Obstetrics and Gynecology |
| title | Angiogenic Factors and Renal Disease in Pregnancy |
| title_full | Angiogenic Factors and Renal Disease in Pregnancy |
| title_fullStr | Angiogenic Factors and Renal Disease in Pregnancy |
| title_full_unstemmed | Angiogenic Factors and Renal Disease in Pregnancy |
| title_short | Angiogenic Factors and Renal Disease in Pregnancy |
| title_sort | angiogenic factors and renal disease in pregnancy |
| url | http://dx.doi.org/10.1155/2011/281391 |
| work_keys_str_mv | AT juliesrhee angiogenicfactorsandrenaldiseaseinpregnancy AT brettcyoung angiogenicfactorsandrenaldiseaseinpregnancy AT saroshrana angiogenicfactorsandrenaldiseaseinpregnancy |