The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis
Abstract Glioblastoma multiforme (GBM) is a common central nervous system malignancy with poor survival despite new treatments. Although some evidence demonstrated the prognostic effects of metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) and urothelial carcinoma associated 1 (UCA1) l...
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| Format: | Article |
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Wiley
2025-06-01
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| Series: | Precision Medical Sciences |
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| Online Access: | https://doi.org/10.1002/prm2.70003 |
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| author | Sedighe Hooshmandi Ehsan Jangholi Amirreza Heidarian Mahsa Dehghani Ali Ghassemi Aida Heidary Ali Rezvanimehr Erfan Sadeghi Seyed Mohammad Ghodsi Mohammad Hoseinian Mostafa Farzin Hamid Zaferani Arani Mahmoudreza Hadjighassem |
| author_facet | Sedighe Hooshmandi Ehsan Jangholi Amirreza Heidarian Mahsa Dehghani Ali Ghassemi Aida Heidary Ali Rezvanimehr Erfan Sadeghi Seyed Mohammad Ghodsi Mohammad Hoseinian Mostafa Farzin Hamid Zaferani Arani Mahmoudreza Hadjighassem |
| author_sort | Sedighe Hooshmandi |
| collection | DOAJ |
| description | Abstract Glioblastoma multiforme (GBM) is a common central nervous system malignancy with poor survival despite new treatments. Although some evidence demonstrated the prognostic effects of metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) and urothelial carcinoma associated 1 (UCA1) long non‐coding RNAs (lncRNAs) in patients with GBM, a comprehensive study has not yet evaluated the clinical importance of these lncRNAs. Hence, this review aimed to predict the significance of expressions of MALAT and UCA1 lncRNAs in patients with GBM. Using proper keywords, a thorough literature search was performed via databases, including PubMed, Web of Knowledge, Scopus, and EMBASE until December 2024. The relationship between lncRNA expressions and overall survival (OS) in patients with GBM was assessed using hazard ratios (HR) and confidence intervals (95% CI), and the fixed and random effects models were used to estimate the pooled effect size. Also, the Newcastle‐Ottawa Quality Assessment Scale was used as an appraisal tool. Among 1553 initially founded records, 13 studies were enrolled in the final analysis, consisting of 915 and 257 samples in the MALAT1 and UCA1 groups, respectively. Compared to the patients with low expression, those with high expression of MALAT1 had a mortality risk of 80% (HR = 1.8, 95% CI = [1.39, 2.33], p = .001). Additionally, the impact of UCA1 expression on patient prognosis indicated that lower OS among patients was correlated with high expression of UCA1; however, the meta‐analysis was not performed for UCA1 due to a lack of adequate studies. According to our findings, high expression of MALAT1 was correlated with poor prognosis in patients with GBM. |
| format | Article |
| id | doaj-art-e09ebf99bd4b436283f90f9532fb20b6 |
| institution | OA Journals |
| issn | 2642-2514 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj-art-e09ebf99bd4b436283f90f9532fb20b62025-08-20T02:21:24ZengWileyPrecision Medical Sciences2642-25142025-06-01142667410.1002/prm2.70003The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysisSedighe Hooshmandi0Ehsan Jangholi1Amirreza Heidarian2Mahsa Dehghani3Ali Ghassemi4Aida Heidary5Ali Rezvanimehr6Erfan Sadeghi7Seyed Mohammad Ghodsi8Mohammad Hoseinian9Mostafa Farzin10Hamid Zaferani Arani11Mahmoudreza Hadjighassem12Medical Imaging Research Center, Department of Radiology Shiraz University of Medical Sciences Shiraz IranBrain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran IranDepartment of Radiology Shohada Hospital, Shahid Beheshti University of Medical Sciences Tehran IranFaculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch Tehran IranFaculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch Tehran IranFaculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch Tehran IranFaculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch Tehran IranDepartment of Biostatistics School of Medicine, Shiraz University of Medical Sciences Shiraz IranBrain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran IranBrain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran IranBrain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran IranDepartment of Surgery Shiraz University of Medical Sciences Shiraz IranBrain and Spinal Cord Injury Research Center, Neuroscience Institute Tehran University of Medical Sciences Tehran IranAbstract Glioblastoma multiforme (GBM) is a common central nervous system malignancy with poor survival despite new treatments. Although some evidence demonstrated the prognostic effects of metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) and urothelial carcinoma associated 1 (UCA1) long non‐coding RNAs (lncRNAs) in patients with GBM, a comprehensive study has not yet evaluated the clinical importance of these lncRNAs. Hence, this review aimed to predict the significance of expressions of MALAT and UCA1 lncRNAs in patients with GBM. Using proper keywords, a thorough literature search was performed via databases, including PubMed, Web of Knowledge, Scopus, and EMBASE until December 2024. The relationship between lncRNA expressions and overall survival (OS) in patients with GBM was assessed using hazard ratios (HR) and confidence intervals (95% CI), and the fixed and random effects models were used to estimate the pooled effect size. Also, the Newcastle‐Ottawa Quality Assessment Scale was used as an appraisal tool. Among 1553 initially founded records, 13 studies were enrolled in the final analysis, consisting of 915 and 257 samples in the MALAT1 and UCA1 groups, respectively. Compared to the patients with low expression, those with high expression of MALAT1 had a mortality risk of 80% (HR = 1.8, 95% CI = [1.39, 2.33], p = .001). Additionally, the impact of UCA1 expression on patient prognosis indicated that lower OS among patients was correlated with high expression of UCA1; however, the meta‐analysis was not performed for UCA1 due to a lack of adequate studies. According to our findings, high expression of MALAT1 was correlated with poor prognosis in patients with GBM.https://doi.org/10.1002/prm2.70003glioblastoma multiformlong non‐coding RNAMALATsurvivalUCA1 |
| spellingShingle | Sedighe Hooshmandi Ehsan Jangholi Amirreza Heidarian Mahsa Dehghani Ali Ghassemi Aida Heidary Ali Rezvanimehr Erfan Sadeghi Seyed Mohammad Ghodsi Mohammad Hoseinian Mostafa Farzin Hamid Zaferani Arani Mahmoudreza Hadjighassem The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis Precision Medical Sciences glioblastoma multiform long non‐coding RNA MALAT survival UCA1 |
| title | The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis |
| title_full | The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis |
| title_fullStr | The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis |
| title_full_unstemmed | The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis |
| title_short | The role of MALAT1 and UCA1 long non‐coding RNAs on the prognosis of patients with glioblastoma: A systematic review and meta‐analysis |
| title_sort | role of malat1 and uca1 long non coding rnas on the prognosis of patients with glioblastoma a systematic review and meta analysis |
| topic | glioblastoma multiform long non‐coding RNA MALAT survival UCA1 |
| url | https://doi.org/10.1002/prm2.70003 |
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